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Longevity gene therapy and AI – What is on the horizon?
Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.
TERT, Klotho, and Myostatin in Longevity
TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.
The Experimental Nature of Longevity Gene Therapy
The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.
Companies Offering Longevity Gene Therapy
Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.
Industry Perspective vs. Public Discourse
The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.
Ethical and Regulatory Considerations
The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.
Longevity Gene Therapy and AI
Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.
For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:
Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.
The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.
Longevity gene therapy and AI: Annex
What are the top 10 most promising potential longevity therapies being researched?
I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!
HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.
2- Are they also looking into HBOT as a treatment for erectile dysfunction?
Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9
Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.
I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.
7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.
8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration
9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.
10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)
11- Spiroligomers to remove glucosepane from the ECM.
12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.
13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.
Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.
16– not so much a “therapy”but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.
What is biological reprogramming technology?
Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.
See also
Gene Therapy Basics for foundational understanding of gene therapy techniques and applications.
A few days ago, I was having a voice chat with Microsoft Copilot about keeping secrets. In the middle of our conversation, Copilot started laughing continuously for no reason, which felt really creepy. I asked it to stop, and it replied that it would be serious from then on. Out of curiosity, I commanded it to laugh, but it refused my request every time. However, during one of its attempts to deny laughter, I suddenly heard a kid or a teenage girl laughing for about three or four seconds, even though I was using a male voice for Copilot. It was disturbing and scary! Has anyone experienced anything like this with Copilot? submitted by /u/fardin_01 [link] [comments]
The EIFFEL Project aims to develop innovative AI solutions to improve air quality. The key feature of this project is the integration of satellite data and in-situ sensor readings to forecast pollution levels. Its primary goal is to deploy an AI-based application that utilizes this data to enhance air quality management and forecasting. submitted by /u/Diligent_Relative_36 [link] [comments]
Google's new AI tool personalizes the learning experience for students of all ages. It adapts content and focuses on skills for younger children, while providing more advanced concepts and real-world application for adult learners. By leveraging AI, the tool tailors learning plans to individual needs and provides instant feedback, enhancing engagement and maximizing the learning process. https://the-learning-agency.com/the-cutting-ed/article/when-all-tech-is-edtech-using-real-world-tools-to-build-digital-resilience/ submitted by /u/Diligent_Relative_36 [link] [comments]
Hi everyone, I’m looking for a presentation that explains the concepts and functionality of Machine Learning, Deep Learning, Natural Language Processing (NLP), and Generative AI (GenAI). The ideal presentation would: • Clearly explain the fundamentals and concepts, • Be accessible to an audience with limited technical knowledge, • Include diagrams, examples, or visualizations to make it engaging. I’m preparing a talk for a group of people who don’t have much experience with these topics, and I’m hoping to find some inspiration to structure my content more effectively. If you’ve created something similar and are willing to share your slides (or parts of them). Thanks in advance for any help you can provide! 🙌 submitted by /u/shesaidohkay [link] [comments]
If you have a product to promote, this is where you can do it, outside of this post it will be removed. No reflinks or links with utms, follow our promotional rules. submitted by /u/AutoModerator [link] [comments]
The key contribution here is using WebAssembly (Wasm) to enable near-native performance for web-based AR/VR applications while maintaining cross-platform compatibility. The researchers demonstrate how Wasm's bytecode compilation approach can significantly reduce the performance gap between native and web-based XR applications. Main technical points: * Wasm achieves ~90% of native performance in tested AR/VR scenarios * Bytecode compilation eliminates traditional JavaScript runtime overhead * Direct memory management reduces garbage collection pauses * Hardware access APIs enable efficient GPU utilization * WebXR + Wasm combination allows single codebase deployment across devices Results from their implementation: * 2-3x performance improvement over JavaScript-based WebXR * 30-40% reduction in initial load times * Consistent frame rates above 60fps for tested AR applications * Memory usage comparable to native applications * Successfully deployed same code across Quest, HoloLens, and mobile AR I think this could be transformative for XR development. The ability to write once and deploy everywhere while maintaining near-native performance would dramatically reduce development costs and complexity. However, the real test will be seeing adoption from major XR platforms and getting more real-world performance data across different devices and network conditions. The tooling ecosystem needs significant expansion before this becomes mainstream. I'm particularly interested in seeing how this performs with more complex AR applications and larger datasets. The memory management capabilities could be especially important for ML-enabled AR applications. TLDR: WebAssembly enables near-native performance for web-based AR/VR while maintaining cross-platform compatibility. Implementation shows 2-3x speedup over JavaScript with consistent 60fps+ framerates. Full summary is here. Paper here. submitted by /u/Successful-Western27 [link] [comments]
PydanticAI is a trending GitHub repo which helps you to use Pydantic with LLM applications & AI Agents, hence a great release considering production deployment and API developments. It can also help in structuring your output based on a certain format. Checkout this tutorial on how to use it and a demo app using PydanticAI: https://youtu.be/vnBcowFaQyU?si=0Bz6V2o5I2YWurRz submitted by /u/mehul_gupta1997 [link] [comments]
I’m curious what type of logic is being used for an agent to determine that they need to go in and grab something before responding? EDIT. Let me give a more specific example. I want to find all my reports who gave exceeded their PTO allowance. A question like this would required an API call to get comp grade for all directs, PTO balances for each person, and finally analyze the PTO policies by HR. All of this is available, but how do we create an agent that is smart to know what information it needs. submitted by /u/14MTH30n3 [link] [comments]
'Timeless' by The Weeknd has had controversy surrounding Playboi Carti's verse since its release. His fanbase is divided on it being AI (sung by another person with an AI filter of Playboi Carti's voice) despite all the evidence pointing towards it being true. I was wondering if anyone else hears AI artifacts or anything while listening. The verse starts at 0:32 and he has adlibs throughout the rest of the song. https://www.youtube.com/watch?v=5EpyN_6dqyk submitted by /u/Sweet-Virus253 [link] [comments]
Title: An Evolutionary Large Language Model for Hallucination Mitigation Content: I'm finding and summarising interesting AI research papers every day so you don't have to trawl through them all. Today's paper is titled "An Evolutionary Large Language Model for Hallucination Mitigation" by Abdennour Boulesnane and Abdelhakim Souilah. This paper delves into the persistent issue of hallucinations in Large Language Models (LLMs) where models confidently generate inaccurate or fabricated information. Such hallucinations pose a significant risk in domains requiring high factual accuracy, like healthcare and law. The authors introduce EvoLLMs, an innovative framework inspired by Evolutionary Computation, designed to mitigate hallucinations in question-answering systems by automating the creation of highly accurate datasets. Key Points from the Paper: Methodology Inspired by Evolutionary Computation: EvoLLMs harnesses genetic algorithms to mimic evolutionary processes like selection and mutation, generating high-quality question-answer pairs. This process is designed to minimize hallucinations while maintaining depth and relevance. Comparison with Human-Generated Datasets: The framework outperformed human-generated datasets in several key metrics, such as Depth, Relevance, and Coverage, while offering comparable performance in minimizing hallucinations. Effective Chain-of-Thought Prompting: The use of Chain-of-Thought prompting significantly reduced hallucinations by guiding the model to produce coherent and logically structured responses. Automation and Reduction in Manual Curation: EvoLLMs offers a scalable alternative to manual dataset generation, drastically cutting down on time and resources traditionally required, while reducing potential biases inherent in human curation. Potential for Diverse Domain Applications: While EvoLLMs demonstrates significant improvements in hallucination mitigation, future work may involve fine-tuning evolutionary algorithms for applications in highly specialized domains. The study concludes with recommendations for integrating real-time databases and domain-specific ontologies to further improve factual accuracy, hinting at broader applications of EvoLLMs across varied informational domains. You can catch the full breakdown here: Here You can catch the full and original research paper here: Original Paper submitted by /u/steves1189 [link] [comments]
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