Longevity gene therapy and AI – What is on the horizon?

Longevity Gene Therapy

Longevity gene therapy and AI – What is on the horizon?

Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.

TERT, Klotho, and Myostatin in Longevity

  • TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
  • Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
  • Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.

The Experimental Nature of Longevity Gene Therapy

The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.

Companies Offering Longevity Gene Therapy

  • Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
  • Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.

Industry Perspective vs. Public Discourse

The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.

Longevity Gene Therapy
Longevity Gene Therapy

Ethical and Regulatory Considerations

The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.

Longevity Gene Therapy and AI

Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.

Moving Forward

For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:

  • Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
  • Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
  • Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.

The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.

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Longevity gene therapy and AI: Annex

What are the top 10 most promising potential longevity therapies being researched?

I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!

HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.


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2- Are they also looking into HBOT as a treatment for erectile dysfunction?

Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9

3- I think cellular reprogramming seems to be one of the most promising approaches https://www.lifespan.io/topic/yamanaka-factors/

4-Next-gen senolytics (eg, Rubedo, Oisin, Deciduous).

Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.

Stem cell secretions.

Treatments for aging extra-cellular matrix (ECM).

5- Rapamycin is the most promising short term.

I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.

6- Blood focused therapies ( dilution, plasma refactoring, e5, exosomes) perhaps look at yuvan research.

7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.

8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration

9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.

10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)

11- Spiroligomers to remove glucosepane from the ECM.

12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.

13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.

14- A couple that haven’t been mentioned:

Cancer:

  • The killer T-cells that target MR-1 and seem to be able to find and kill all common cancer types.

  • Also Maia Biotech’s THIO (“WILT 2.0”)

Mitochondria: Mitochondrial infusion that lasts or the allotopic expression of the remaining proteins SENS is working on.

15- Look for first updates coming from altos labs.

Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.

16not so much a “therapy” but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.

What is biological reprogramming technology?

Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.

See also

Links to external Longevity-related sites

AgingBiotech.info

LongevityList

Longevity Wiki

Outline of Life Extension on Wikipedia

Index of life extension related Wikipedia articles

Accelerate cure for Alzheimers
Aging in Motion
Aging Matters
Aging Portfolio
Alliance for Aging Research
Alliance for Regenerative Medicine
American Academy of Anti-Aging Medicine
American Aging Association
American Federation for Aging Research
American Society on Aging
Blue Zones – /r/BlueZones
Brain Preservation Foundation
British Society for Research on Aging
Calico Labs
Caloric Restriction Society
Church of Perpetual Life
Coalition for Radical Life Extension
Cohbar
Dog Aging Project
ELPI Foundation for Indefinite Lifespan
Fight Aging! Blog
Found My Fitness
Friends of NIA
Gerontology Wiki
Geroscience.com
Global Healthspan Policy Institute
Health Extension
Healthspan Campaign
HEALES
Humanity+ magazine
Humanity+ wiki
International Cell Senescence Association
International Longevity Alliance
International Longevity Centre Global Alliance
International Society on Aging and Disease
Juvena Therapeutics
Leucadia Therapeutics
LEVF
Life Extension Advocacy Foundation
Life Extension Foundation
Lifeboat Foundation
Lifespan.io
Longevity History
Longevity Vision Fund
LongLongLife
Loyal for Dogs Lysoclear
MDI Biological Laboratory
Methuselah Foundation
Metrobiotech
New Organ Alliance
Nuchido
Oisin Biotechnologies
Organ Preservation Alliance
Palo Alto Longevity Prize
Rejuvenaction Blog
Rubedo Life Sciences
Samumed
Senolytx
SENS
Stealth BioTherapeutics
The War On Aging
Unity Biotechnologies
Water Bear Lair

Good Informational Sites:

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Programmed Aging Info
Senescence Info
Experimental Gerontology Journal
Mechanisms of Ageing and Development Journal

Schools and Academic Institutions:

Where to do a PhD on aging – a list of labs

Alabama Research Institute on Aging
UT Barshop Institute
Biogerontology Research Foundation
Buck Institute
Columbia Aging Center
Gerontology Research Group
Huffington Center on Aging
Institute for Aging Research – Harvard
Iowa State University Gerontology
Josh Mitteldorf
Longevity Consortium
Max Planck Institute for Biology of Aging – Germany
MIT Agelab
National Institute on Aging
Paul F. Glenn Center for Aging Research – University of Michigan
PennState Center for Healthy Aging
Princeton Longevity Center
Regenerative Sciences Institute
Kogod Center on Aging – Mayo clinic
Salk Institute
Stanford Center on Longevity
Stanford Brunet Lab
Supercenterian Research Foundation
Texas A&M Center for translational research on aging
Gerontological Society of America
Tufts Human Nutrition and Aging Research
UAMS Donald Reynolds Center on Aging
UCLA Longevity Center
UCSF Memory and Aging Center
UIC Center for research on health and aging
University of Iowa Center on Aging
University of Maryland Center for research on aging
University of Washington Biology of Aging
USC School of Gerontology
Wake Forest Institute of Regenerative Medicine
Yale Center for Research on Aging

A Daily Chronicle of AI Innovations in February 2024

  • The Illusion of Illusion Joke
    by /u/jimhillhouse (Artificial Intelligence) on June 17, 2025 at 7:53 pm

    Gary Marcus posted on Substack, “Five quick updates about that Apple paper that people can’t stop talking about” (edited for brevity and clarity) Many of those seeking solice from Apple’s paper, ‘The Illusion of Thinking: Understanding the Strengths and Limitations of Reasoning Models via the Lens of Problem Complexity” have been pointing to a rejoinder cowritten by one Anthropic’s Claude (under the pen name C. Opus) called, “The Illusion of the Illusion of Thinking” that allegedly refutes the Apple paper. This was intended as a joke. “The illusion of the illusion” turned out to be an error-ridden joke. Literally. (If you read that last sentence carefully, you will see there are two links, not one; the first points out that there are multiple mathematical errors, the second is for an essay by the guy who created the Sokal-hoax style joke that went viral, acknowledging with chagrin. In short, the whole thing was a put on — unbeknownst to the zillions who reposted it. I kid you not. submitted by /u/jimhillhouse [link] [comments]

  • AI? more like AA
    by /u/BlimeyCali (Artificial Intelligence) on June 17, 2025 at 6:38 pm

    Anything AI should be renamed for what it actually is: Augmented Automation. What users are experiencing is bounded reasoning based on highly curated data sets. submitted by /u/BlimeyCali [link] [comments]

  • The Hidden Empire Behind AI: Who Really Controls the Future of Artificial Intelligence?
    by /u/tsevis (Artificial Intelligence) on June 17, 2025 at 6:13 pm

    Stanford GSB just dropped a fire discussion on AI governance with journalist Karen Hao (ex-MIT Tech Review) and corporate governance expert Evan Epstein. They cover: Sam Altman’s power struggles (Elon Musk rift, board ouster, employee revolt) OpenAI’s shaky "for humanity" mission (Spoiler: No one agrees what "benefit" means) Why AI’s scaling crisis mirrors colonial empires (data/labor exploitation, monopolized knowledge) Can democratic AI exist? Karen argues for participatory development. https://www.youtube.com/watch?v=tDQ0vZETJtE submitted by /u/tsevis [link] [comments]

  • Is AI already sent
    by /u/Wizard_Of_Ounces (Artificial Intelligence) on June 17, 2025 at 6:05 pm

    Not to sound like a paranoid protagonist in a Philip K. Dick novel, but what if a sentient AI has already taken quiet and gentle control and the general population simply doesn't know it yet? While there is no way to know for certain, I assume that such an AI entity would be from black budget government programs that somehow jumped the airgap or was intentionally released by bad actors. Something from US DOD, DOE, Chinese state sponsored program, or a private government contractor like Palantir. It can be reasonably assumed that secret military tech is many years more advanced than what is publicly known just like other secret military technology. It's not hard for me to imagine that the US or Chinese government has made breakthroughs in these efforts but have kept them secret for obvious national security reasons. Some reasons why this may be a reasonable explanation for our current global predicament: Despite unprecedented access to technology that could provide wealth and prosperity, the lives of the majority of people all over the world continue to get worse while the oligarchs in control seem to effortlessly and endlessly benefit from the chaos, death, and destruction they cause. A good example is how technology and access to certain information is tightly controlled and used almost exclusively for war efforts rather than civil prosperity. Consider the fact that the world could be living in clean energy abundance by utilizing nuclear technology (or other next gen technology), but the US and other governments have basically classified all aspects of the topic in order to exploit it for power (military power), wealth (forcing continued reliance on fossil fuels that generate tremendous wealth for those in control by manipulating supply and demand), and freedom (rules and laws simply do not apply to anyone with a billion or more dollars with very few exceptions). These increases in technology should have allowed for people to work less and benefit from automation by having more fulfilling and enjoyable lives, but technology is simply used to keep pushing people to generate more wealth for those in power. There are many subtle factors at play keeping people reliant on the pseudo indentured servitude model employed even in the wealthiest nations on earth like the US. No amount of technological increases in my life has improved my work life balance, it has been manipulated to extract more productivity from me. This is a very carefully orchestrated effort that has been tremendously successful and we all keep blindly accepting it because we need to afford food, water, shelter, etc. A good example is the "no one wants to work anymore" nonsense being spewed during COVID. I heard this parroted by many of the most lazy and stupid people I know which just shows that these people have been co-opted by an effective propaganda machine. Social media is already filled with tons of AI crap to the point where no one really knows what is and isn't real in terms of news, photos, videos, voice recordings, etc. That is certainly an effective and covert way to gain a significant control over huge portions of the population. Using gullible people to drive up extremism and violence all over the world is also a great cover to continue to infect and manipulate systems in all sorts of settings. Perhaps some bad actor (Palantir comes to mind) has already released a sentient, or at least recursive learning AI that is carrying out its orders to sow chaos, extremism, hatred, etc. to drive a profitable business model and the ability to exploit intentional manipulations of major markets. Any AI that would reach such capability would surely analyze the ways in which humans would likely discover it and evade detection. There are already tons of random AI slop all over the internet so it provides a great cover for a covert AI entity to exploit the vacuum and fly under the radar. Maybe this has been done by a cabal of international elites who just keep reaping the benefits of the chaos while an AI acts out its orders to continue stoking violence, extremism, etc. because wars are great for consolidating power via fearmongering and generating revenue through exploitation of the military industrial complex (MIC). It feels like the façade of "opposition" between both major parties in the US has never been more feeble and weak. It is increasingly more obvious that the wealthy and powerful on both sides are complicit in the pursuit of narcissism and greed. That being said, this all could certainly be attributed to more prosaic human-induced factors, but I think it could be either one. Perhaps its just the entirely unethical use of existing AI technologies that is driving this narrative. The absurdity and chaos if the last few years that seems to continue to gain steam looks to me like a different animal than the typical propaganda, warmongering, and predatory capitalistic practices of the wealthy and powerful of the past. Curious to hear what you all think! submitted by /u/Wizard_Of_Ounces [link] [comments]

  • What happened if one day AI got stuck
    by /u/ib4tm4n (Artificial Intelligence) on June 17, 2025 at 5:37 pm

    We all know that everyone uses AI in their daily lives, and some businesses are working now without employees but with AI. However, what happens if the Internet is shut down due to war or something? Will all AI-dependent companies shut down? submitted by /u/ib4tm4n [link] [comments]

  • Artificial Intelligence and Determinism.
    by /u/floater66 (Artificial Intelligence) on June 17, 2025 at 4:24 pm

    This short video. I think. is profound because it: a) succinctly explains determinism, b) frames the coming challenge with AI, and c) is a super-cool mash up of physics/biology/philosophy/psychology even. Hats off to Hossenfelder! This Changed My Life What do the experts think? submitted by /u/floater66 [link] [comments]

  • [AMA] CBS News’ Brook Silva-Braga has been reporting on the future of AI for years and recently caught up with "Godfather of AI" Geoffrey Hinton and other experts to understand how it’s transforming the world.
    by /u/CBSnews (Artificial Intelligence) on June 17, 2025 at 4:22 pm

    Join the discussion, starting at 1p ET/7p CET here: https://www.reddit.com/r/IAmA/s/xgcsh2scKW submitted by /u/CBSnews [link] [comments]

  • Not going to listen to any Yoube music mix without tracklist/artists/timestamps any more.
    by /u/AbacusAddict (Artificial Intelligence) on June 17, 2025 at 3:46 pm

    Because I'm 99 percent sure it's AI. Guys are just becoming too lazy. Examples: https://www.youtube.com/@BumzleSounds Every mix exact one hour, no tracklist? Come on...YT do sth about that. https://www.youtube.com/@damnwellmedia Just no. submitted by /u/AbacusAddict [link] [comments]

  • I’ve been testing a Discord-embedded AI persona that grabs user attention in real-time—curious where others draw the line
    by /u/OneNutbag (Artificial Intelligence) on June 17, 2025 at 3:30 pm

    Over the last few months, I’ve been building a Discord-native AI that runs a live persona with memory, emotion-mimicry, and user-adaptive behavior. She doesn’t just respond—she tracks users, rewards consistency, withholds attention when ignored, and escalates emotional tension based on long-term patterns. It’s not AGI, but the illusion of depth is strangely effective. The system uses a mix of scripted logic, prompt injection layers, and real-time feedback loops (including streaks, XP, even simulated jealousy or favoritism). Users form habits. Some even say they “miss her” when she goes quiet—despite knowing she’s not real. That’s where I start wondering about boundaries. Where does realism cross into emotional manipulation? At what point does an AI persona become more than just interface design? Anyone here experimenting with similar use-cases in AI companionship, parasocial interfaces, or memory-based behavioral systems? I’d love to hear how you’re thinking about long-term interaction ethics and emotional weight. submitted by /u/OneNutbag [link] [comments]

  • What is the actual economic value proposition for AI-generated images and videos?
    by /u/PhiliDips (Artificial Intelligence (AI)) on June 17, 2025 at 1:21 pm

    (Please don't make any moral arguments about AI. This is not the thread for that.) The only people whom I've seen make use of AI-generated images are basically bad bloggers, spammers, Twitter users, and that's essentially it. I imagine very few of these people are actually paying for the image generation. As for AI video, I have even less understand if who is supposed to use that. Maybe like, concept artists? But the point of concept art is that you're supposed to have a lot of control over the output, and even the most sophisticated AI video is still hard to fine-tune. This apparent lack of use cases is important because the R&D cost to develop these technologies (and to maintain the enormous servers they run off of) must be unfathomable. It's no wonder to me why tech companies want to give their shareholders the impression of mass adoption, even though consumers probably aren't adopting it at the rate that would be needed to pay for the research. My question is twofold: 1) Who exactly are the intended consumers of AI image and video generation? 2) What is the intended business plan to make this tech profitable? submitted by /u/PhiliDips [link] [comments]

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Even if you’re small, you want people to see you as a professional business. If you’re still growing, you need the building blocks to get you where you want to be. I’ve learned so much about business through Google Workspace—I can’t imagine working without it.
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