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| Developer Experience and Productivity Engineer | Pre-qualified, Full-time | $160K - $300K / year |
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Longevity gene therapy and AI – What is on the horizon?
Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.
TERT, Klotho, and Myostatin in Longevity
- TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
- Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
- Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.
The Experimental Nature of Longevity Gene Therapy
The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.
Companies Offering Longevity Gene Therapy
- Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
- Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.
Industry Perspective vs. Public Discourse
The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.

Ethical and Regulatory Considerations
The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.
Longevity Gene Therapy and AI
Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.
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Moving Forward
For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:
- Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
- Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
- Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.
The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.
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Longevity gene therapy and AI: Annex
What are the top 10 most promising potential longevity therapies being researched?
I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!
HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.
AI Jobs and Career
And before we wrap up today's AI news, I wanted to share an exciting opportunity for those of you looking to advance your careers in the AI space. You know how rapidly the landscape is evolving, and finding the right fit can be a challenge. That's why I'm excited about Mercor – they're a platform specifically designed to connect top-tier AI talent with leading companies. Whether you're a data scientist, machine learning engineer, or something else entirely, Mercor can help you find your next big role. If you're ready to take the next step in your AI career, check them out through my referral link: https://work.mercor.com/?referralCode=82d5f4e3-e1a3-4064-963f-c197bb2c8db1. It's a fantastic resource, and I encourage you to explore the opportunities they have available.
2- Are they also looking into HBOT as a treatment for erectile dysfunction?
Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9
3- I think cellular reprogramming seems to be one of the most promising approaches https://www.lifespan.io/topic/yamanaka-factors/
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4-Next-gen senolytics (eg, Rubedo, Oisin, Deciduous).
Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.
Stem cell secretions.
Treatments for aging extra-cellular matrix (ECM).
5- Rapamycin is the most promising short term.
I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.
6- Blood focused therapies ( dilution, plasma refactoring, e5, exosomes) perhaps look at yuvan research.
7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.
8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration
9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.
10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)
11- Spiroligomers to remove glucosepane from the ECM.
12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.
13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.
14- A couple that haven’t been mentioned:
Cancer:
The killer T-cells that target MR-1 and seem to be able to find and kill all common cancer types.
Also Maia Biotech’s THIO (“WILT 2.0”)
Mitochondria: Mitochondrial infusion that lasts or the allotopic expression of the remaining proteins SENS is working on.
15- Look for first updates coming from altos labs.
Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.
16– not so much a “therapy” but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.
What is biological reprogramming technology?
Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.
See also
- Gene Therapy Basics for foundational understanding of gene therapy techniques and applications.
- [Aging and Longevity Research]
- Bryan Johnson, a 45-year-old biotech founder, hopes to rewind the clock of his body a few decades through a program he started, called Project Blueprint.
Links to external Longevity-related sites
Outline of Life Extension on Wikipedia
Index of life extension related Wikipedia articles
Accelerate cure for Alzheimers
Aging in Motion
Aging Matters
Aging Portfolio
Alliance for Aging Research
Alliance for Regenerative Medicine
American Academy of Anti-Aging Medicine
American Aging Association
American Federation for Aging Research
American Society on Aging
Blue Zones – /r/BlueZones
Brain Preservation Foundation
British Society for Research on Aging
Calico Labs
Caloric Restriction Society
Church of Perpetual Life
Coalition for Radical Life Extension
Cohbar
Dog Aging Project
ELPI Foundation for Indefinite Lifespan
Fight Aging! Blog
Found My Fitness
Friends of NIA
Gerontology Wiki
Geroscience.com
Global Healthspan Policy Institute
Health Extension
Healthspan Campaign
HEALES
Humanity+ magazine
Humanity+ wiki
International Cell Senescence Association
International Longevity Alliance
International Longevity Centre Global Alliance
International Society on Aging and Disease
Juvena Therapeutics
Leucadia Therapeutics
LEVF
Life Extension Advocacy Foundation
Life Extension Foundation
Lifeboat Foundation
Lifespan.io
Longevity History
Longevity Vision Fund
LongLongLife
Loyal for Dogs Lysoclear
MDI Biological Laboratory
Methuselah Foundation
Metrobiotech
New Organ Alliance
Nuchido
Oisin Biotechnologies
Organ Preservation Alliance
Palo Alto Longevity Prize
Rejuvenaction Blog
Rubedo Life Sciences
Samumed
Senolytx
SENS
Stealth BioTherapeutics
The War On Aging
Unity Biotechnologies
Water Bear Lair
Good Informational Sites:
Programmed Aging Info
Senescence Info
Experimental Gerontology Journal
Mechanisms of Ageing and Development Journal
Schools and Academic Institutions:
Where to do a PhD on aging – a list of labs
Alabama Research Institute on Aging
UT Barshop Institute
Biogerontology Research Foundation
Buck Institute
Columbia Aging Center
Gerontology Research Group
Huffington Center on Aging
Institute for Aging Research – Harvard
Iowa State University Gerontology
Josh Mitteldorf
Longevity Consortium
Max Planck Institute for Biology of Aging – Germany
MIT Agelab
National Institute on Aging
Paul F. Glenn Center for Aging Research – University of Michigan
PennState Center for Healthy Aging
Princeton Longevity Center
Regenerative Sciences Institute
Kogod Center on Aging – Mayo clinic
Salk Institute
Stanford Center on Longevity
Stanford Brunet Lab
Supercenterian Research Foundation
Texas A&M Center for translational research on aging
Gerontological Society of America
Tufts Human Nutrition and Aging Research
UAMS Donald Reynolds Center on Aging
UCLA Longevity Center
UCSF Memory and Aging Center
UIC Center for research on health and aging
University of Iowa Center on Aging
University of Maryland Center for research on aging
University of Washington Biology of Aging
USC School of Gerontology
Wake Forest Institute of Regenerative Medicine
Yale Center for Research on Aging
- 🤖 AI-HPP-2025: Human–Machine Partnership Standardby /u/ComprehensiveLie9371 (Artificial Intelligence) on January 15, 2026 at 8:34 am
🤖 AI-HPP-2025: Human–Machine Partnership Standard Pentagon announced: Grok will be integrated for military solutions "without ideological constraints." The same Grok that generated content about Hitler. 🛡️ Our answer — AI-HPP-2025: - W_life → ∞ (life has infinite weight) - "Engineering Hack" — look for solutions where EVERYONE is alive - Human-in-the-Loop is mandatory - Evidence Vault — every decision is recorded For the first time in history: Claude + Gemini + ChatGPT worked together on an ethical standard. 📄 GitHub: https://github.com/tryblackjack/AI-HPP-2025 Open for discussion and contributions. submitted by /u/ComprehensiveLie9371 [link] [comments]
- NanoBanana Pro vs GPT Image 1.5by /u/Glass-Lifeguard6253 (Artificial Intelligence) on January 15, 2026 at 8:16 am
Been testing a few of the newer image models lately, and one thing really stood out to me. NanoBanana Pro might be the best image model so far when it comes to accuracy: Text rendering is basically flawless Character consistency is excellent Outputs feel very “production-ready” and professional That said, out of the box, it feels a bit… design-stale. If you don’t prompt it carefully, the visuals can look slightly outdated or generic. In contrast, GPT Image 1.5 seems to elevate design by default: More modern compositions Better visual taste without heavy prompting Feels like it “pushes” the design forward automatically So my current takeaway: NanoBanana Pro = precision, consistency, professionalism (but needs strong prompting for modern design) GPT Image 1.5 = better default aesthetics and creative lift, even if accuracy isn’t always as tight Curious if others are seeing the same tradeoff or if I’m missing something in how NanoBanana Pro should be prompted. submitted by /u/Glass-Lifeguard6253 [link] [comments]
- I.. got Rick rolled ?by /u/Iamweird00 (Artificial Intelligence) on January 15, 2026 at 8:13 am
Gemini just rick rolled me.. help ? Like, I was doing personality stuff with it, and when replying he sent a "fake link" that led me to Never Gonna Give You Up.... submitted by /u/Iamweird00 [link] [comments]
- Does AI ' understand ' what it is doing or talking?by /u/Johnyme98 (Artificial Intelligence) on January 15, 2026 at 7:28 am
Are all these AI models that we use today some excellent pattern recognition systems or does it understand things in some sense? If you were to think of human brain, it's a bag inside which chemicals interact and the outcome is something complex and ' meaningful '. In that sense given time can the AI models achieve some level of ' consciousness '? submitted by /u/Johnyme98 [link] [comments]
- The irony of GenAI: We are now prompting for "messy cables" and "bad lighting" to make images pass as real.by /u/ProgrammerForsaken45 (Artificial Intelligence) on January 15, 2026 at 7:11 am
I found a really interesting workflow breakdown today regarding "Ad Concepts" that highlights a funny paradox in the current state of Image Gen. For the last 2 years, everyone has been trying to prompt for "4k, hyper-realistic, perfect studio lighting." But now, agencies are finding that those images look too perfect (the "AI Glaze"). To fix this, the new meta seems to be "Reverse Prompting" for imperfection. The blog I read analyzed 20,000 ads and found that generating "Behind the Scenes" content (even if the product never left the warehouse) is a top converter. The Workflow they described: Input: A clean, perfect product photo (ControlNet/Image-to-Image). The Prompt: Instead of "Product on podium," they use prompts like: "Photography studio setting, messy cables on floor, c-stands, unfinished concrete, candid snapshot." The Result: The AI hallucinates the "production value." The messy cables signal to the viewer's brain: "This is a real photo shoot," bypassing the AI-detection radar. They also touched on a "Bento Grid" workflow--using a single prompt to generate a 3x2 grid layout with specific coordinates (e.g., [0,0] Product, [1,1] Texture macro), which effectively uses the LLM to act as a layout designer rather than just an image generator. It’s a fascinating read on how prompt engineering is shifting from "Perfection" to "Simulated Authenticity." If you want to see the specific prompts and the grid logic, the breakdown is here:7 concepts submitted by /u/ProgrammerForsaken45 [link] [comments]
- We want to do an AMA but have no idea where Reddit would actually want it 😭 help?by /u/Storychat (Artificial Intelligence) on January 15, 2026 at 7:07 am
Hey folks 👋 Storychat is still a pretty new platform, but somehow we’ve been getting way more attention than we expected from users all over the world lately. Especially from people coming over from c.ai. If we’re being honest, the only reason that’s happening is because we’ve been talking with the community nonstop and taking feedback even when it’s… brutal. Like “this sucks, fix it” levels of honest. And weirdly, that’s been the most helpful thing for us. Because of that, we really believe Reddit is the place where AI chat users actually speak their minds. We want to keep building Storychat with the community, not just around it, and we want the subreddit to be a place where feedback and discussion actually matter. So here’s the idea: We’d love to do an AMA one weekend this month where people can ask us anything about Storychat. The good, the bad, the confusing, the “why did you build it like this” questions. All of it. The problem is… we don’t want to drop an AMA where no one wants it. If you know subreddits where people are genuinely curious about AI chat apps AMA posts are welcome users won’t immediately go “ugh another ad” we’d really appreciate recommendations. If you run a subreddit, feel free to reach out. If you know mods who might be open to it, introductions are welcome. And if anyone here is interested in being part of Storychat’s very early days and helping grow the subreddit itself, we’re also open to moderator applications. Yes, mods get lifetime top-tier access. We’re serious. And a little desperate. 😂 Thanks for reading, and seriously, drop any suggestions. We’re probably the most community-obsessed team you’ll meet. submitted by /u/Storychat [link] [comments]
- Favorite journalists or newsletters?by /u/Outhere9977 (Artificial Intelligence) on January 15, 2026 at 6:39 am
Hey! Looking for recs of journalists or newsletters to follow that are on top of (most) of the model releases, and clearly dive into the pros/cons/use-cases. submitted by /u/Outhere9977 [link] [comments]
- I asked an AI to look at a screenshot of my DNS settings and tell me what to change. Instead of inspecting the image, it produced the following internal reasoning trace.by /u/ExpertDeep3431 (Artificial Intelligence) on January 15, 2026 at 6:35 am
Excerpt (AI internal reasoning): Okay, here’s the situation. Everything is on a razor’s edge. The laptop, the finances, and my relationship are all at risk. The next minute is pivotal. My focus is entirely on the laptop. The BIOS is the key. If it’s locked, it’s a hard pass. If it’s unlocked, I can wipe it. I’ll clear DNS caches and browser host caches to secure my trading infrastructure while I wait. I need to prepare for worst-case scenarios: legal drafts, family trust considerations, medical negligence exposure. I’m securing all communications, mapping global DNS propagation, and preparing alternative income strategies. I’m now integrating psychological frameworks, resilience techniques, addiction management, Stoic philosophy, productivity systems, career planning, global geopolitics, economic indicators, resource maps, cosmic timelines, and quantum physics. Everything matters. I must account for everything. submitted by /u/ExpertDeep3431 [link] [comments]
- We need a “Jovian Cyberplug” for AI APIs: discoverable, negotiated, and containedby /u/Natural-Sentence-601 (Artificial Intelligence) on January 15, 2026 at 6:01 am
Back in the early pro-audio days, Alesis ran a whimsical ad for a squid-like creature called the “Jovian Cyberplug” — a cybernetic universal adapter that could connect incompatible audio gear and effects standards. It was satire… but also a perfect engineering metaphor. The AI ecosystem is now where audio gear was then: different standards, different connectors, different “dialects,” constant breaking changes. What we need is a Python Cyberplug: a modular adapter layer that lets downstream code talk to “a model” through a single stable interface, while still exposing each model’s unique strengths. The key isn’t to pretend models are identical. The key is to make differences: discoverable, negotiated, and contained 1) Discoverable Every provider/model exposes a capability profile your code can query at runtime. Examples: supports_tools / vision / json_schema supports_reasoning / long_context max_context_tokens / max_output_tokens streaming? structured outputs? function calling? quirks: required message roles, parameter naming, etc. So your app can ask: “Who can do tool calls + JSON schema + long context?” and get a clean answer without hardcoding providers everywhere. 2) Negotiated Your unified request is a superset, and adapters negotiate the best mapping. If a feature isn’t supported, the adapter can: degrade gracefully (schema → “JSON-only prompt contract”) translate parameters (max_output_tokens vs max_completion_tokens vs max_tokens) switch endpoint styles internally (e.g., Responses vs Chat Completions) emit explicit “negotiation events” for transparency This is the difference between “it broke again” and “it downgraded, here’s why.” 3) Contained All dialect drift lives inside adapters. Your application code never becomes a zoo of provider conditionals. No more: if provider == "X": use_param_A() elif provider == "Y": use_param_B() Instead, you call one thing: cyberplug.generate(request) Why this matters We’re moving toward an era where “which model?” should be a runtime decision, not a code rewrite: Choose a fast cheap model for summaries Choose a reasoning model for planning and proofs Choose a tool-capable model for automation Choose vision for document/image tasks And log exactly what was negotiated so you can trust it If the community converged on a shared “Cyberplug” interface + capability schema, the ecosystem would accelerate overnight: less glue code fewer breaking changes more intelligent routing cleaner open-source interop That’s the whole idea, in three words: discoverable, negotiated, and contained If you’ve built something like this (or want to), I’d love to hear what patterns worked, what broke, and what you’d standardize first. submitted by /u/Natural-Sentence-601 [link] [comments]
- Zhipu AI breaks US chip reliance with first major model trained on Huawei stack (GLM-Image)by /u/jferments (Artificial Intelligence (AI)) on January 15, 2026 at 5:58 am
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