Longevity gene therapy and AI – What is on the horizon?

Longevity Gene Therapy

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Longevity gene therapy and AI – What is on the horizon?

Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.

TERT, Klotho, and Myostatin in Longevity

  • TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
  • Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
  • Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.

The Experimental Nature of Longevity Gene Therapy

The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.

Companies Offering Longevity Gene Therapy

  • Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
  • Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.

Industry Perspective vs. Public Discourse

The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.

Longevity Gene Therapy
Longevity Gene Therapy

Ethical and Regulatory Considerations

The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.

Longevity Gene Therapy and AI

Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.

Moving Forward

For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:

  • Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
  • Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
  • Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.

The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.

Longevity gene therapy and AI: Annex

What are the top 10 most promising potential longevity therapies being researched?

I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!

HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.

2- Are they also looking into HBOT as a treatment for erectile dysfunction?

Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9

3- I think cellular reprogramming seems to be one of the most promising approaches https://www.lifespan.io/topic/yamanaka-factors/

4-Next-gen senolytics (eg, Rubedo, Oisin, Deciduous).

Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.

Stem cell secretions.

Treatments for aging extra-cellular matrix (ECM).

5- Rapamycin is the most promising short term.

I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.

6- Blood focused therapies ( dilution, plasma refactoring, e5, exosomes) perhaps look at yuvan research.

7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.

8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration

9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.


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10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)

11- Spiroligomers to remove glucosepane from the ECM.

12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.

13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.

14- A couple that haven’t been mentioned:

Cancer:

  • The killer T-cells that target MR-1 and seem to be able to find and kill all common cancer types.

  • Also Maia Biotech’s THIO (“WILT 2.0”)

Mitochondria: Mitochondrial infusion that lasts or the allotopic expression of the remaining proteins SENS is working on.

15- Look for first updates coming from altos labs.

Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.

16not so much a “therapy” but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.

What is biological reprogramming technology?

Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.

See also

Links to external Longevity-related sites

AgingBiotech.info

LongevityList

Longevity Wiki

Outline of Life Extension on Wikipedia

Index of life extension related Wikipedia articles

Accelerate cure for Alzheimers
Aging in Motion
Aging Matters
Aging Portfolio
Alliance for Aging Research
Alliance for Regenerative Medicine
American Academy of Anti-Aging Medicine
American Aging Association
American Federation for Aging Research
American Society on Aging
Blue Zones – /r/BlueZones
Brain Preservation Foundation
British Society for Research on Aging
Calico Labs
Caloric Restriction Society
Church of Perpetual Life
Coalition for Radical Life Extension
Cohbar
Dog Aging Project
ELPI Foundation for Indefinite Lifespan
Fight Aging! Blog
Found My Fitness
Friends of NIA
Gerontology Wiki
Geroscience.com
Global Healthspan Policy Institute
Health Extension
Healthspan Campaign
HEALES
Humanity+ magazine
Humanity+ wiki
International Cell Senescence Association
International Longevity Alliance
International Longevity Centre Global Alliance
International Society on Aging and Disease
Juvena Therapeutics
Leucadia Therapeutics
LEVF
Life Extension Advocacy Foundation
Life Extension Foundation
Lifeboat Foundation
Lifespan.io
Longevity History
Longevity Vision Fund
LongLongLife
Loyal for Dogs Lysoclear
MDI Biological Laboratory
Methuselah Foundation
Metrobiotech
New Organ Alliance
Nuchido
Oisin Biotechnologies
Organ Preservation Alliance
Palo Alto Longevity Prize
Rejuvenaction Blog
Rubedo Life Sciences
Samumed
Senolytx
SENS
Stealth BioTherapeutics
The War On Aging
Unity Biotechnologies
Water Bear Lair

Good Informational Sites:

Programmed Aging Info
Senescence Info
Experimental Gerontology Journal
Mechanisms of Ageing and Development Journal

Schools and Academic Institutions:

Where to do a PhD on aging – a list of labs

Alabama Research Institute on Aging
UT Barshop Institute
Biogerontology Research Foundation
Buck Institute
Columbia Aging Center
Gerontology Research Group
Huffington Center on Aging
Institute for Aging Research – Harvard
Iowa State University Gerontology
Josh Mitteldorf
Longevity Consortium
Max Planck Institute for Biology of Aging – Germany
MIT Agelab
National Institute on Aging
Paul F. Glenn Center for Aging Research – University of Michigan
PennState Center for Healthy Aging
Princeton Longevity Center
Regenerative Sciences Institute
Kogod Center on Aging – Mayo clinic
Salk Institute
Stanford Center on Longevity
Stanford Brunet Lab
Supercenterian Research Foundation
Texas A&M Center for translational research on aging
Gerontological Society of America
Tufts Human Nutrition and Aging Research
UAMS Donald Reynolds Center on Aging
UCLA Longevity Center
UCSF Memory and Aging Center
UIC Center for research on health and aging
University of Iowa Center on Aging
University of Maryland Center for research on aging
University of Washington Biology of Aging
USC School of Gerontology
Wake Forest Institute of Regenerative Medicine
Yale Center for Research on Aging

A Daily Chronicle of AI Innovations in February 2024

  • Any struggling college student should use notebooklm
    by /u/Dunnofam12 (Artificial Intelligence Gateway) on November 14, 2024 at 2:29 pm

    Im a 5th year university student and learned about notebooklm while researching ways to study a certain subject thats extremely advanced when i learned its free and made by google i had to give it a shot, basically you upload all your pdfs for the material you want to learn (a limit of 30 pdfs each time) and it analyzes the pdfs you sent it and basically becomes a master of it, you can ask it any question you have about the pdfs you uploaded and it will answer it so well, but the best feature in my opinion is the podcast feature, it basically creates a recording of two people discussing the material youve given it and it sounds so human and genuine its unreal, they make information flow like butter and turn the material into something so fun and easy to understand like they know what theyre talking about, so any college or uni student should really give it a shot. Ps: it has OCR built in it so you dont have to worry about it not being able to read certain tables or charts, its a big help for me in equations that are pictures submitted by /u/Dunnofam12 [link] [comments]

  • OpenAI’s next ‘giant breakthrough’ tipped to land soon and control your computer
    by /u/gurugabrielpradipaka (Artificial Intelligence Gateway) on November 14, 2024 at 2:02 pm

    https://www.techradar.com/computing/artificial-intelligence/openais-next-giant-breakthrough-tipped-to-land-soon-and-control-your-computer OpenAI is rumored to be launching new AI agent tool in January Report claims it's codenamed Operator and can control your browser This help could help it write code or book travel on your behalf submitted by /u/gurugabrielpradipaka [link] [comments]

  • ChatGPT is a hell of a good psychologist
    by /u/tetsu_originalissimo (Artificial Intelligence Gateway) on November 14, 2024 at 1:53 pm

    Maybe somewhat of a unpopular opinion, but chatGPT (or other AI counterparts for that matter) is a hella good psychologist. I've tried (more like was "forced" by my parents) to go to the psychologist when young, but it never worked, and I concluded it was not for me. I just couldn't talk about anything and the sugestions were all pretty pointless (I tried more than one for the record). So I just used sports to cope, and it worked pretty well, but recently I had very little time for training and a injury that prevented me to do so and was going a little insane (also really stressed with unrelated stuff) so one day, (feeling pathetic about it) I typed some stuff in for of poetry for GTP, and it fellt great, although the response was also a little pointless it was like talking to someone without actually having to worry about it being turned against me. so it became something that I would do in some nights that I couldn't sleep and it has somewhat helped. Also after that I sometimes ask it to describe my situation and me in general based on previous conversations and DAMN it is accurate. idk why i'm posting this, but if someone wants to try it out I definitely recommend. submitted by /u/tetsu_originalissimo [link] [comments]

  • Best Certification For an AI role
    by /u/butterfly-angela (Artificial Intelligence Gateway) on November 14, 2024 at 1:52 pm

    For context I’m in a 3 rd year Majoring Mathematics and Computer Student . If you are in the AI industry / Hr what are the most “sought” after AI certifications. submitted by /u/butterfly-angela [link] [comments]

  • Is erasing of 100T bits (volume of human brain synapses) equal to murder?
    by /u/Any-Blacksmith-2054 (Artificial Intelligence Gateway) on November 14, 2024 at 1:23 pm

    Just listened to Lex Fridman podcast and they discussed emotional/romantic connection to AI. If they will not clear context each session and allow it to grow up to 100 trillions, will it be equal to human by law? submitted by /u/Any-Blacksmith-2054 [link] [comments]

  • Reddit is full of AI content being passed off as real for karma, followers, and likes.
    by /u/Temporary-Spell3176 (Artificial Intelligence Gateway) on November 14, 2024 at 1:04 pm

    (Food subreddits) - Full of AI photos of plates of different food. Highly Realistic food pictures are easy to make with right image generators. Saw many fake ai food images with tons of likes. (Support subreddits) - People answering others questions with AI replies and just pasting questions into LLMs to give correct answers to help people and get likes (Art subreddits) - People making realistic ai images of different mediums of art and passing it off as if they made it. Ex. "Drawings". (Animal subreddits) - Once again, realistic ai photos of animals can easily be made and be passed off as if any Iphone took the picture. (Advice/Story subreddits) - Full of intriguing/wild stories can be made using ai to grab a reader in. Easy to get an ai to make a random story to fit a certain subreddit and generate likes. Every month, new AI generators come out along with language models. We are advancing at alarming rates when it comes to tech. Dont be gullible. Not everything you see is real people. I see it again and again, especially on reddit of fake images or stories getting thousands of likes. submitted by /u/Temporary-Spell3176 [link] [comments]

  • Pros and cons of Google labeling AI-generated content in search and ads.
    by /u/Capable-Start-5497 (Artificial Intelligence Gateway) on November 14, 2024 at 12:57 pm

    submitted by /u/Capable-Start-5497 [link] [comments]

  • Do you fear the future?
    by /u/MPM_SOLVER (Artificial Intelligence Gateway) on November 14, 2024 at 12:57 pm

    In just few years, agent will take over the jobs based on computers, I used to think that it will take a long time, but consider that there are some tools to automate comfyui, at that time, I think unemployment will aggravate, and wealth will concentrate to few people, and we also may have war, the AI driven kill machines will be deployed, AI generated fake news and propaganda will cripple democracy and tear the society apart. Let alone the climate change, human civilization is collapsing submitted by /u/MPM_SOLVER [link] [comments]

  • Why so much hype around crewAI?
    by /u/HappyDataGuy (Artificial Intelligence Gateway) on November 14, 2024 at 11:39 am

    I recently saw apple's career page asking for experience in crewAI. I don't really understand the hype around it since in my experience its nothing special on the contrary its not intuitive, limited and generally lacks projects so that we can learn from them. In my experience at least, dspy was much better than this and you could understand whats really happening. What do you guys think? am i missing something? submitted by /u/HappyDataGuy [link] [comments]

  • Phone network employs AI "grandmother" to waste scammers' time with meandering conversations
    by /u/gurugabrielpradipaka (Artificial Intelligence Gateway) on November 14, 2024 at 11:27 am

    https://www.techspot.com/news/105571-phone-network-employs-ai-grandmother-waste-scammers-time.html Human-like AIs have brought plenty of justifiable concerns about their ability to replace human workers, but a company is turning the tech against one of humanity's biggest scourges: phone scammers. The AI imitates the criminals' most popular target, a senior citizen, who keeps the fraudsters on the phone as long as possible in conversations that go nowhere, à la Grandpa Simpson. submitted by /u/gurugabrielpradipaka [link] [comments]

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