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Longevity gene therapy and AI – What is on the horizon?
Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.
TERT, Klotho, and Myostatin in Longevity
TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.
The Experimental Nature of Longevity Gene Therapy
The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.
Companies Offering Longevity Gene Therapy
Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.
Industry Perspective vs. Public Discourse
The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.
Ethical and Regulatory Considerations
The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.
Longevity Gene Therapy and AI
Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.
For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:
Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.
The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.
Longevity gene therapy and AI: Annex
What are the top 10 most promising potential longevity therapies being researched?
I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!
HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.
2- Are they also looking into HBOT as a treatment for erectile dysfunction?
Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9
Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.
I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.
7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.
8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration
9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.
10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)
11- Spiroligomers to remove glucosepane from the ECM.
12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.
13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.
Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.
16– not so much a “therapy”but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.
What is biological reprogramming technology?
Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.
See also
Gene Therapy Basics for foundational understanding of gene therapy techniques and applications.
I want to learn AI, but I don't know the best way to do it because I am currently a beginner in Python and SQL, which I studied in college. I also studied math and statistics in college. Can anyone suggest how I can develop my skills and advance in this field? submitted by /u/Own_Hawk2887 [link] [comments]
Hi, can active recommend a video tool that specifically can handle the following. I have two cartoon characters. I have 1,000 scripts already created with sone instructions for charachter facial expressions, arm gestures, walking etc Want to create 1,000 videos (can do one at a time but batches preferred) Video of 1 minute each ai generated from the upload of the two character images and a text file that includes instructions for expressions, actions such as walking.. and script of dialogue. Text to speak has to be multiple languages - japanese.. korean.. malay etc Auto captions of the speech and other captions we might want to add I have developed that can integrate with an API if needed and can format script and instructions into whatever file format needed etc. Basically animation from i struction and script created automatically Any advice welcome. It’s for social enterprise and free service. submitted by /u/Far_Incident_8999 [link] [comments]
In a world awash with AI-generated deepfakes, we’re stepping into what can only be described as the “Deep Doubt” era. Remember when you could look at a photo or video and believe it captured reality? Well, those days are fading fast, as AI tools are making it easier to create convincing fakes. But the real twist? Now, anyone can dismiss genuine evidence as just another AI trick. Whether it’s a viral image, a political rally, or even a historical record, it’s becoming harder to know what’s real anymore. What Is “Deep Doubt” Anyway? Deep doubt is the new wave of skepticism bred by the rise of AI-generated media, especially deepfakes. With AI able to create photos, videos, and even voices that mimic reality, people are starting to question everything—even legitimate, fact-based media. This dangerous trend lets people more easily claim that things didn’t happen, pointing to AI as a scapegoat. For instance, in recent months, former President Donald Trump claimed an image with E. Jean Carroll (the writer who sued him for sexual assault) was an AI fabrication. Spoiler: it wasn’t. The “Liar’s Dividend”: How Doubt Became a Tool Back in 2019, legal scholars Danielle Citron and Robert Chesney coined the term "liar's dividend." It’s a neat way of saying: "If everyone thinks something could be fake, liars can claim everything is fake." Simple, right? In practice, though, it's much more alarming. Think about a politician caught on camera saying something incriminating—well, now they can just shrug and say, "It’s probably AI." And a surprising number of people will believe it. We’re seeing this play out everywhere. For example, conspiracy theorists have used AI to push wild claims that public figures—like President Joe Biden—are holograms or digitally created. If you thought your aunt’s Facebook feed was bad before, it’s about to get worse. How We Got Here: A History of Manipulated Media Manipulating media isn’t new. Even before Photoshop, photographers would crop, frame, and manipulate images. It’s just that AI has made it so much easier. Thanks to AI deepfakes, a high schooler in their basement can now create a video of your favorite actor doing or saying just about anything. All they need is a few hours and the right tools. And with each new breakthrough in AI tech, these fakes get more lifelike—and the lies more believable. The Rise of Deep Doubt in Politics and Law It’s not just social media users causing chaos. The real implications of deep doubt hit when it infects more serious areas, like politics and the legal system. Federal judges are already nervous about deepfakes being used to introduce fake evidence into trials or to undermine real evidence. Imagine trying to convict someone based on video footage, only to have the defense argue, "That’s not real; it’s AI." This uncertainty stretches beyond the courtroom. It’s seeping into how we talk about history. Could AI-manipulated media rewrite our understanding of past events? With deepfakes, historical photos and footage—once seen as ironclad proof—could be called into question. If we can’t trust our records, where does that leave us? The Social Fallout: Trust is on Life Support Our trust in online content is eroding fast, and deep doubt is driving us further down the rabbit hole. Enter the “Dead Internet Theory,” a growing conspiracy that claims most online interactions are generated by AI and bots. The fact that it’s so easy to imagine this as true shows just how deep doubt has spread. What’s next? If we stop trusting what we see online, social trust could unravel. It’s already happening as conspiracy theories fester in spaces where AI deepfakes and misinformation thrive. Even tech giants like Microsoft have raised alarms about a potential “post-epistemic world”—a world where fact and fiction blur so much that no one can tell them apart. How to Fight Deep Doubt: Context, Credibility, and Common Sense So, how do we combat deep doubt in this AI-warped world? The key lies in context. Just as a historian would verify a centuries-old parchment by cross-referencing sources, we must do the same with digital media today. Verifying a suspicious video or image means looking for multiple corroborating sources—different angles of the event, original reporting, and reputable eyewitness accounts. It's not enough to trust a single screenshot or viral post. Relying on trustworthy, verified accounts is our best shot at discerning truth from AI-generated fiction. Even though AI detection tools exist, they aren’t foolproof and can often give false results. In the end, good old-fashioned critical thinking, combined with credible sourcing, remains our best defense against deep doubt. Conclusion: Welcome to the New Normal (Unfortunately) As the line between real and fake continues to blur, we’re all going to need to be a little more skeptical—and a lot more vigilant. AI has opened Pandora’s box, and now anyone can weaponize deep doubt to sow confusion, undermine the truth, and erode social trust. The only question left is: How long until we stop believing anything we see online? submitted by /u/These-Salary-9215 [link] [comments]
Generative AI (Gen AI) is a cutting-edge form of artificial intelligence (AI) that can generate new data like images, text, or even code. Unlike traditional AI used for analysis, Gen AI delves deeper to generate new insights and possibilities. Learn in detail about Generative AI and its techniques, application, and impact on businesses. Ever wondered how Baymax scans the body effortlessly, providing the vital stats and diagnosis of the person with preventive measures for any medical issue? Well, it will be considered an AI-generated response. We have not yet reached that stage in AI and healthcare, however, Gen AI is making a lot of movements in the healthcare sector by enabling more accurate diagnoses, personalized treatments, and accelerated drug discovery with healthcare AI companies taking the lead. Read: https://www.seaflux.tech/blogs/genai-impact-in-healthcare-industry submitted by /u/Sandyrocks77 [link] [comments]
How are the latest advancements in AI changing the way digital assistants provide personalized experiences? What specific features do you find most impactful? submitted by /u/CLEVERTONE1 [link] [comments]
Have you heard the buzz about NPUs? If not, you’re about to—because neural processing units (NPUs) are set to become a game-changer for personal computers. You’ve heard of CPUs and GPUs, but NPUs are the next big thing in hardware, and soon, most PCs will have them. But what exactly are they, and why are they so important? NPU 101: What is it? NPU stands for Neural Processing Unit. It’s a specialized processor designed to handle AI and machine learning tasks much more efficiently than traditional CPUs or GPUs. Think of NPUs as AI accelerators—they boost the performance of AI features without draining your battery or heating up your device. How Do NPUs Work? AI tasks, like image recognition or language processing, rely on something called neural networks. NPUs are optimized to process these networks faster and with less power consumption. While GPUs are great at AI tasks, they require lots of energy. NPUs, on the other hand, hit the sweet spot by offering a balance between performance and efficiency. NPU vs. CPU vs. GPU: The Breakdown CPU (Central Processing Unit): Your PC’s brain, handling general tasks. GPU (Graphics Processing Unit): Focused on handling complex graphics and gaming, but also useful for AI work. NPU (Neural Processing Unit): The AI specialist, running tasks like voice assistants, image processing, and more—without hogging system resources or battery life. Why Do NPUs Matter? If you’ve ever run AI tools like ChatGPT or Stable Diffusion on your PC, you might have noticed they’re power-hungry and slow down your machine. NPUs can run these tasks faster and more efficiently. Plus, they free up your CPU and GPU for other tasks, meaning your entire system runs smoother. NPUs in Action: What Can They Do? Windows PCs with NPUs can run AI-powered features, like Microsoft’s Windows Studio Effects (think background blurring on video calls or automatic eye contact correction). In the future, more apps will take advantage of NPUs, offering smoother AI-enhanced experiences—from audio and video editing to gaming. What’s the Catch? Right now, not every PC has an NPU. But brands like Intel, AMD, and Qualcomm are starting to pack them into their newest chips. So, if you're shopping for a new laptop, it’s something to keep an eye on. Should You Get a PC with an NPU Now? It’s tempting to future-proof your device, but NPUs are still in their early stages. For most people, they’re a nice-to-have, not a need-to-have—yet. Many AI tools still run on the cloud, meaning your current hardware will work fine. But if you're looking to stay ahead of the curve, picking up a PC with an NPU could be a smart move for AI-heavy tasks. The AI revolution is just getting started, and NPUs will be at the heart of it. Whether you’re a gamer, creator, or just want a smoother PC experience, NPUs are set to make everything faster, smarter, and more efficient. Note: i used chatgpt to rewrite and make it better due to lack of my English skills submitted by /u/These-Salary-9215 [link] [comments]
By bringing together researchers, practitioners, and nonprofit organizations, G42 and Microsoft are creating a collaborative environment for developing best practices in responsible AI. This partnership is a step toward global AI governance. With endorsement from the UAE’s AIATC and support from both the US and UAE governments, this partnership has significant geopolitical implications. It shows how AI can be regulated and advanced responsibly at an international level. Could this partnership influence global AI policy and regulation? source link: https://www.mediaoffice.abudhabi/en/technology/g42-and-microsoft-to-establish-two-research-centres-in-abu-dhabi-to-advance-development-of-responsible-artificial-intelligence/ submitted by /u/jealousrooster88 [link] [comments]
I want to create floor plans in bulk. If possible with 1 click 🙂 Also a 3d render would be great. Is there an AI app that can do that? I don't need anything professional. It's more important for me to do them really quickly and in bulk. submitted by /u/vovr [link] [comments]
Apologies if I'm not using the correct terms, I just started to get into AI and I'm not super-knowledgable at the moment. This came to mind the other day - I have this video that's otherwise good but it was saved at a lower resolution than it should have been, so it lacks detail in some areas. (You know how if you send someone a video via email on the iPhone it prompts you to send it in a lower resolution? It's that kind of situation.) It occurred to me that maybe an AI could analyze the video and fill in the gaps with generative AI. Here's my logic. Let's say you have a low-quality photo of a wooden fence. You can tell it's a wooden fence (and if you asked an AI they would say it's a wooden fence) but it lacks those finer details like wood grain. So you feed it into the AI, it says "ah, that's a wooden fence and wooden fences have wood grain" and then fills in the grain because that's what it would expect. It uses the photo or image as a baseline and only makes minor changes rather than altering the whole thing, like it might if you said "redo this image in cartoon style" or something like that. I played around with this concept in DiffusionBee but the AI wasn't picking up what I was putting down. Depending on settings like prompt strength, it would either not do anything or give me what was almost a whole new image inspired by the base image. I'm no AI expert so maybe I wasn't using the right search terms, but I did some Googling and it doesn't seem like there's an easy way to do this. Other image tools like Topaz kind of helped but clearly it's not doing that "generative" aspect like I was referring to. It's also a bit hard to tell how tools like Topaz actually work, because it's kind of a black box and obviously they aren't going to spill the beans on their proprietary method. Is there a reason why this is so hard? It seems like it might be an obvious solution to improving video or images that are somewhat lower quality. submitted by /u/UnfoldedHeart [link] [comments]
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