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AI Jobs and Career
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- Full Stack Engineer [$150K-$220K]
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|---|---|---|
| Full-Stack Engineer | Strong match, Full-time | $150K - $220K / year |
| Developer Experience and Productivity Engineer | Pre-qualified, Full-time | $160K - $300K / year |
| Software Engineer - Tooling & AI Workflows (Contract) | Contract | $90 / hour |
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Longevity gene therapy and AI – What is on the horizon?
Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.
TERT, Klotho, and Myostatin in Longevity
- TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
- Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
- Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.
The Experimental Nature of Longevity Gene Therapy
The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.
Companies Offering Longevity Gene Therapy
- Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
- Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.
Industry Perspective vs. Public Discourse
The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.

Ethical and Regulatory Considerations
The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.
Longevity Gene Therapy and AI
Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.
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Moving Forward
For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:
- Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
- Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
- Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.
The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.
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Longevity gene therapy and AI: Annex
What are the top 10 most promising potential longevity therapies being researched?
I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!
HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.
AI Jobs and Career
And before we wrap up today's AI news, I wanted to share an exciting opportunity for those of you looking to advance your careers in the AI space. You know how rapidly the landscape is evolving, and finding the right fit can be a challenge. That's why I'm excited about Mercor – they're a platform specifically designed to connect top-tier AI talent with leading companies. Whether you're a data scientist, machine learning engineer, or something else entirely, Mercor can help you find your next big role. If you're ready to take the next step in your AI career, check them out through my referral link: https://work.mercor.com/?referralCode=82d5f4e3-e1a3-4064-963f-c197bb2c8db1. It's a fantastic resource, and I encourage you to explore the opportunities they have available.
2- Are they also looking into HBOT as a treatment for erectile dysfunction?
Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9
3- I think cellular reprogramming seems to be one of the most promising approaches https://www.lifespan.io/topic/yamanaka-factors/
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4-Next-gen senolytics (eg, Rubedo, Oisin, Deciduous).
Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.
Stem cell secretions.
Treatments for aging extra-cellular matrix (ECM).
5- Rapamycin is the most promising short term.
I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.
6- Blood focused therapies ( dilution, plasma refactoring, e5, exosomes) perhaps look at yuvan research.
7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.
8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration
9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.
10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)
11- Spiroligomers to remove glucosepane from the ECM.
12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.
13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.
14- A couple that haven’t been mentioned:
Cancer:
The killer T-cells that target MR-1 and seem to be able to find and kill all common cancer types.
Also Maia Biotech’s THIO (“WILT 2.0”)
Mitochondria: Mitochondrial infusion that lasts or the allotopic expression of the remaining proteins SENS is working on.
15- Look for first updates coming from altos labs.
Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.
16– not so much a “therapy” but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.
What is biological reprogramming technology?
Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.
See also
- Gene Therapy Basics for foundational understanding of gene therapy techniques and applications.
- [Aging and Longevity Research]
- Bryan Johnson, a 45-year-old biotech founder, hopes to rewind the clock of his body a few decades through a program he started, called Project Blueprint.
Links to external Longevity-related sites
Outline of Life Extension on Wikipedia
Index of life extension related Wikipedia articles
Accelerate cure for Alzheimers
Aging in Motion
Aging Matters
Aging Portfolio
Alliance for Aging Research
Alliance for Regenerative Medicine
American Academy of Anti-Aging Medicine
American Aging Association
American Federation for Aging Research
American Society on Aging
Blue Zones – /r/BlueZones
Brain Preservation Foundation
British Society for Research on Aging
Calico Labs
Caloric Restriction Society
Church of Perpetual Life
Coalition for Radical Life Extension
Cohbar
Dog Aging Project
ELPI Foundation for Indefinite Lifespan
Fight Aging! Blog
Found My Fitness
Friends of NIA
Gerontology Wiki
Geroscience.com
Global Healthspan Policy Institute
Health Extension
Healthspan Campaign
HEALES
Humanity+ magazine
Humanity+ wiki
International Cell Senescence Association
International Longevity Alliance
International Longevity Centre Global Alliance
International Society on Aging and Disease
Juvena Therapeutics
Leucadia Therapeutics
LEVF
Life Extension Advocacy Foundation
Life Extension Foundation
Lifeboat Foundation
Lifespan.io
Longevity History
Longevity Vision Fund
LongLongLife
Loyal for Dogs Lysoclear
MDI Biological Laboratory
Methuselah Foundation
Metrobiotech
New Organ Alliance
Nuchido
Oisin Biotechnologies
Organ Preservation Alliance
Palo Alto Longevity Prize
Rejuvenaction Blog
Rubedo Life Sciences
Samumed
Senolytx
SENS
Stealth BioTherapeutics
The War On Aging
Unity Biotechnologies
Water Bear Lair
Good Informational Sites:
Programmed Aging Info
Senescence Info
Experimental Gerontology Journal
Mechanisms of Ageing and Development Journal
Schools and Academic Institutions:
Where to do a PhD on aging – a list of labs
Alabama Research Institute on Aging
UT Barshop Institute
Biogerontology Research Foundation
Buck Institute
Columbia Aging Center
Gerontology Research Group
Huffington Center on Aging
Institute for Aging Research – Harvard
Iowa State University Gerontology
Josh Mitteldorf
Longevity Consortium
Max Planck Institute for Biology of Aging – Germany
MIT Agelab
National Institute on Aging
Paul F. Glenn Center for Aging Research – University of Michigan
PennState Center for Healthy Aging
Princeton Longevity Center
Regenerative Sciences Institute
Kogod Center on Aging – Mayo clinic
Salk Institute
Stanford Center on Longevity
Stanford Brunet Lab
Supercenterian Research Foundation
Texas A&M Center for translational research on aging
Gerontological Society of America
Tufts Human Nutrition and Aging Research
UAMS Donald Reynolds Center on Aging
UCLA Longevity Center
UCSF Memory and Aging Center
UIC Center for research on health and aging
University of Iowa Center on Aging
University of Maryland Center for research on aging
University of Washington Biology of Aging
USC School of Gerontology
Wake Forest Institute of Regenerative Medicine
Yale Center for Research on Aging
- SMU student loses book deal worth over $2 million after allegations of AI useby /u/Traditional_Figure70 (Artificial Intelligence) on August 13, 2026 at 3:50 pm
(No paywall) A PhD student at Southern Methodist University lost a publishing deal reportedly worth more than $2 million last month after allegations he used AI to write parts of the book. The author, Jerry Falade, denied the claims in a social media post. “I’ll talk when the time is right,” Falade wrote. “Definitely innocent!!!” submitted by /u/Traditional_Figure70 [link] [comments]
- I tested 6 AI interview assistants and turned the results into a public datasetby /u/TheMaerty (Artificial Intelligence) on August 13, 2026 at 3:36 pm
I build CTRLpotato, so obvious disclosure first, all six products I tested are competitors. CTRLpotato isn't included in the results and I'm not using this to declare a winner. Over June and July I tested Cluely, Interview Coder, LockedIn AI, ULTRACODE, Parakeet AI and Final Round AI on Mac and/or Windows. I originally did this because I kept seeing claims like invisible, undetectable, real-time, etc. and wanted to see what the actual desktop apps did. I ended up with enough screenshots, recordings and notes that keeping everything in six separate reviews became pretty useless, so I normalized it into a dataset. It's now 66 assessments across 6 products and 11 criteria. A few results that surprised me: All 6 failed the focus-behavior check in the setup I tested. All 6 failed the cursor-behavior check. Shortcut isolation failed on all 5 products where I tested it. The sixth wasn't tested. I tested receiver-side screen sharing on 4 products. 2 failed and 2 were mixed. There were also some pretty strange context failures, where an assistant would answer an old coding task or otherwise lose track of what it was supposed to be answering. I don't want to oversell those numbers. This wasn't a lab experiment where every product got an identical setup. Different versions, platforms and test flows were involved, which is why every row includes the app version, platform, date, what actually happened, limitations and evidence where I have it. The five result labels are just passed, mixed, failed, not found and not tested. A failure means it failed in the documented setup, not that the feature can never work. The whole thing is public here: https://www.ctrlpotato.com/compare I also put the actual dataset on GitHub with CSV/JSON/JSONL, schema, codebook and checksums: https://github.com/ae0j/ctrlpotato-ai-interview-assistant-benchmark And there's a versioned Zenodo DOI if anyone wants to cite or archive it: https://doi.org/10.5281/zenodo.21915738 The dataset is free to use, including commercially, with attribution. One thing I'm still unsure about: whether the passed/mixed/failed column actually makes the dataset better. The more I worked on this, the more I felt that the raw observation + limitations were more useful than trying to compress what happened into one label. Curious what people who work with evaluation datasets think. submitted by /u/TheMaerty [link] [comments]
- Lost jobs, inequality, rogue agents: why are we accepting oligarchs’ AI agenda? | The dangers of AI become clearer every day. Why are we still acting as if we have no choice about our future?by /u/Silent-Resort-3076 (Artificial Intelligence) on August 13, 2026 at 3:20 pm
Part 1 of 3: Rather than producing jobs, the US economy actually lost 23,000 jobs in July, according to Bureau of Labor Statistics data released on Friday. In addition, May and June’s job numbers were revised downward, showing a combined 103,000 fewer jobs than previously reported. As if this weren’t bad enough, wage growth has also slowed. Average hourly earnings rose by just 0.1% from June. This isn’t just a single month’s slow wage growth, either. Average hourly earnings increased just 3.2% over the past year – the lowest annual growth rate in five years. What’s going on? It’s too early to tell. But evidence is mounting that artificial intelligence is playing a role. New research by economists at Morgan Stanley shows that the rate of unemployment is half a percentage point higher than it would otherwise be in occupations significantly exposed to AI, which they put at about 30% of all employment. The effect is even more dramatic among younger people. Workers in these exposed occupations are also finding it more difficult to transition from unemployment back into employment than workers in less exposed occupations, leading to longer spells of joblessness. And according to research by the economists Sania Edlich and Apollo Global Management’s Torsten Slok, wage growth in jobs exposed to AI has contracted by 6.7% since 2023. This slowdown in wage growth has already resulted in at least $28bn in losses for 5.8 million affected workers. From the end of the article: "Well, then, why can’t we stop the whole thing? Why can’t we decide that, to the vast majority of us, the incalculable costs and risks of AI aren’t worth the potential benefits?" submitted by /u/Silent-Resort-3076 [link] [comments]
- Massachusetts teen accused of killing mother, brother with help from ChatGPTby /u/nbcnews (Artificial Intelligence) on August 13, 2026 at 3:08 pm
submitted by /u/nbcnews [link] [comments]
- [Academic Survey] Employees working in Germany: Attitudes toward AI in the workplace (5–7 min)by /u/miawallace1997 (Artificial Intelligence (AI)) on August 13, 2026 at 2:36 pm
Hi everyone! I'm conducting this survey as part of my Master's thesis and would greatly appreciate your participation. The research examines how employees' perceptions of HR practices relate to work engagement and innovativeness, and how attitudes toward the application of Artificial Intelligence in the workplace influence these relationships. Who can participate? You are currently working in Germany (full-time or part-time). You are 18 years or older. The survey is anonymous, takes 5–7 minutes, and all responses will be used solely for academic research. 👉 Survey: https://pollmill.com/f/xya75pv.f Even if you don't actively use AI at work, your perspective is still valuable—the study focuses on employees' attitudes toward AI in the workplace, not their level of AI usage. Thank you for helping with my research! submitted by /u/miawallace1997 [link] [comments]
- What is the current state of ROI with regard to AI capital ?by /u/Loner_Indian (Artificial Intelligence) on August 13, 2026 at 2:27 pm
So it has been almost 4 years since the world saw its first glimpse of this so called "revolutionary" technology. So where are we with regards to building something profitable and long-lasting like computing was in the 70s . Is buu le inflating or deflating ? Also what is the overall strategy of AI honchos ? What is their long term vision ? Thanks submitted by /u/Loner_Indian [link] [comments]
- Hackers used autonomous AI agents to attack Taiwan. Is this the future of cyberwarfare?by /u/Fcking_Chuck (Artificial Intelligence (AI)) on August 13, 2026 at 2:25 pm
submitted by /u/Fcking_Chuck [link] [comments]
- Cascadia Launches Distributed AI Inference for Intel Hardwareby /u/techne98 (Artificial Intelligence (AI)) on August 13, 2026 at 2:14 pm
submitted by /u/techne98 [link] [comments]
- AI crawlers from Meta and Alibaba almost destroyed a volunteer-run LGBT history archiveby /u/_fastcompany (Artificial Intelligence) on August 13, 2026 at 2:09 pm
submitted by /u/_fastcompany [link] [comments]
- Data Centers in Japanby /u/Top_Course_640 (Artificial Intelligence) on August 13, 2026 at 1:43 pm
I thought this was an interesting example of how Japan is publicly framing data-center development. This is from an official Tsukuba City publication. (Translated via GPT Image 2.0, source images included) What stood out to me is how much space they devote not just to the economic benefits, but to the social contract around the project: noise, heat, electricity demand, groundwater, electromagnetic radiation, landscaping, setbacks from residential areas, disaster resilience, public facilities, community consultation, and even how residents’ concerns are supposed to be handled. Obviously, an official brochure is still an official brochure, so I wouldn’t treat every statement as proof that implementation will be perfect. But I also wouldn’t dismiss this as meaningless PR. In the Japanese municipal context, these are publicly attributable commitments. If the city or developer later behaves in a way that clearly contradicts what was presented to residents, that can become a reputational and political problem. So I think the useful way to read this is: not “every promise is guaranteed,” but “this is a fairly serious statement of what the project is expected to deliver and what standards residents can hold them to.” I find the contrast interesting because data-center discussions elsewhere often seem to start with capacity, investment, AI demand, and power procurement. Here, the public-facing explanation starts almost immediately with: How does this affect the people who already live here? submitted by /u/Top_Course_640 [link] [comments]
























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