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Longevity gene therapy and AI – What is on the horizon?
Gene therapy holds promise for extending human lifespan and enhancing healthspan by targeting genes associated with aging processes. Longevity gene therapy, particularly interventions focusing on genes like TERT (telomerase reverse transcriptase), Klotho, and Myostatin, is at the forefront of experimental research. Companies such as Bioviva, Libella, and Minicircle are pioneering these interventions, albeit with varying degrees of transparency and scientific rigor.
TERT, Klotho, and Myostatin in Longevity
- TERT: The TERT gene encodes for an enzyme essential in telomere maintenance, which is linked to cellular aging. Overexpression of TERT in model organisms has shown potential in lengthening telomeres, potentially delaying aging.
- Klotho: This gene plays a crucial role in regulating aging and lifespan. Klotho protein has been associated with multiple protective effects against age-related diseases.
- Myostatin: Known for its role in regulating muscle growth, inhibiting Myostatin can result in increased muscle mass and strength, which could counteract some age-related physical decline.
The Experimental Nature of Longevity Gene Therapy
The application of gene therapy for longevity remains largely experimental. Most available data come from preclinical studies, primarily in animal models. Human data are scarce, raising questions about efficacy, safety, and potential long-term effects. The ethical implications of these experimental treatments, especially in the absence of robust data, are significant, touching on issues of access, consent, and potential unforeseen consequences.
Companies Offering Longevity Gene Therapy
- Bioviva: Notably involved in this field, Bioviva has been vocal about its endeavors in gene therapy for aging. While they have published some data from mouse studies, human data remain limited.
- Libella and Minicircle: These companies also offer longevity gene therapies but face similar challenges in providing comprehensive human data to back their claims.
Industry Perspective vs. Public Discourse
The discourse around longevity gene therapy is predominantly shaped by those within the industry, such as Liz Parrish of Bioviva and Bryan Johnson. While their insights are valuable, they may also be biased towards promoting their interventions. The lack of widespread discussion on platforms like Reddit and Twitter, especially from independent sources or those outside the industry, points to a need for greater transparency and peer-reviewed research.

Ethical and Regulatory Considerations
The ethical and regulatory landscape for gene therapy is complex, particularly for treatments aimed at non-disease conditions like aging. The experimental status of longevity gene therapies raises significant ethical questions, particularly around informed consent and the potential long-term impacts. Regulatory bodies are tasked with balancing the potential benefits of such innovative treatments against the risks and ethical concerns, requiring a robust framework for clinical trials and approval processes.
Longevity Gene Therapy and AI
Integrating Artificial Intelligence (AI) into longevity gene therapy represents a groundbreaking intersection of biotechnology and computational sciences. AI and machine learning algorithms are increasingly employed to decipher complex biological data, predict the impacts of genetic modifications, and optimize therapy designs. In the context of longevity gene therapy, AI can analyze vast datasets from genomics, proteomics, and metabolomics to identify new therapeutic targets, understand the intricate mechanisms of aging, and predict individual responses to gene therapies. This computational power enables researchers to simulate the effects of gene editing or modulation before actual clinical application, enhancing the precision and safety of therapies. Furthermore, AI-driven platforms facilitate the personalized tailoring of gene therapy interventions, taking into account the unique genetic makeup of each individual, which is crucial for effective and minimally invasive treatment strategies. The synergy between AI and longevity gene therapy accelerates the pace of discovery and development in this field, promising more rapid translation of research findings into clinical applications that could extend human healthspan and lifespan.
Moving Forward
For longevity gene therapy to advance from experimental to accepted medical practice, several key developments are needed:
- Robust Human Clinical Trials: Rigorous, peer-reviewed clinical trials involving human participants are essential to establish the safety and efficacy of gene therapies for longevity.
- Transparency and Peer Review: Open sharing of data and peer-reviewed publication of results can help build credibility and foster a more informed public discourse.
- Ethical and Regulatory Frameworks: Developing clear ethical guidelines and regulatory pathways for these therapies will be crucial in ensuring they are deployed responsibly.
The future of longevity gene therapy is fraught with challenges but also holds immense promise. As the field evolves, a multidisciplinary approach involving scientists, ethicists, regulators, and the public will be crucial in realizing its potential in a responsible and beneficial manner.
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Longevity gene therapy and AI: Annex
What are the top 10 most promising potential longevity therapies being researched?
I think the idea of treating aging as a disease that’s treatable and preventable in some ways is a really necessary focus. The OP works with some of the world’s top researchers using HBOT as part of that process to increase oxygen in the blood and open new pathways in the brain to address cognitive decline and increase HealthSpan (vs. just lifespan). Pretty cool stuff!
HBOT in longevity research stands for “hyperbaric oxygen therapy.” It has been the subject of research for its potential effects on healthy aging. Several studies have shown that HBOT can target aging hallmarks, including telomere shortening and senescent cell accumulation, at the cellular level. For example, a prospective trial found that HBOT can significantly modulate the pathophysiology of skin aging in a healthy aging population, indicating effects such as angiogenesis and senescent cell clearance. Additionally, research has demonstrated that HBOT may induce significant senolytic effects, including increasing telomere length and decreasing senescent cell accumulation in aging adults. The potential of HBOT in healthy aging and its implications for longevity are still being explored, and further research is needed to fully understand its effects and potential applications.
2- Are they also looking into HBOT as a treatment for erectile dysfunction?
Definitely! Dr. Shai Efrati has been doing research around that and had a study published in the Journal of Sexual Medicine. Dr. Efrati and his team found that 80% of men “reported improved erections” after HBOT therapy: https://www.nature.com/articles/s41443-018-0023-9
3- I think cellular reprogramming seems to be one of the most promising approaches https://www.lifespan.io/topic/yamanaka-factors/
4-Next-gen senolytics (eg, Rubedo, Oisin, Deciduous).
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Cellular rejuvenation aka partial reprogramming (as someone else already said) but not just by Yamanaka (OSKM) factors or cocktail variants but also by other novel Yamanaka-factor alternatives.
Stem cell secretions.
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Treatments for aging extra-cellular matrix (ECM).
5- Rapamycin is the most promising short term.
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I see a lot of people saying reprogramming, and I think the idea is promising but as someone who worked on reprogramming cells in vitro I can tell you that any proof of concepts in vivo large animal models is far aways.
6- Blood focused therapies ( dilution, plasma refactoring, e5, exosomes) perhaps look at yuvan research.
7- I think plasmapheresis is a technology most likely to be proven beneficial in the near term and also a technology that can be scaled and offered for reasonable prices.
8- Bioelectricity, if we succeed in interpreting the code of electrical signals By which cells communicate , we can control any tissue growth and development including organs regeneration
9- Gene therapy and reprogramming will blow the lid off the maximum lifespan. Turning longevity genes on/expressing proteins that repair cellular damage and reversing epigenetic changes that occur with aging.
10- I don’t think anything currently being researched (that we know of) has the potential to take us to immortality. That’ll likely end up requiring some pretty sophisticated nanotechnology. However, the important part isn’t getting to immortality, but getting to LEV. In that respect, I’d say senolytics and stem cell treatments are both looking pretty promising. (And can likely achieve more in combination than on their own.)
11- Spiroligomers to remove glucosepane from the ECM.
12- Yuvan Research. Look up the recent paper they have with Steve Horvath on porcine plasma fractions.
13- This OP thinks most of the therapies being researched will end up having insignificant effects. The only thing that looks promising to me is new tissue grown from injected stem cells or outright organ replacement. Nothing else will address DNA damage, which results in gene loss, disregulation of gene expression, and loss of suppression of transposable elements.
14- A couple that haven’t been mentioned:
Cancer:
The killer T-cells that target MR-1 and seem to be able to find and kill all common cancer types.
Also Maia Biotech’s THIO (“WILT 2.0”)
Mitochondria: Mitochondrial infusion that lasts or the allotopic expression of the remaining proteins SENS is working on.
15- Look for first updates coming from altos labs.
Altos Labs is a biotechnology research company focused on unraveling the deep biology of cell rejuvenation to reverse disease and develop life extension therapies that can halt or reverse the human aging process. The company’s goal is to increase the “healthspan” of humans, with longevity extension being an “accidental consequence” of their work. Altos Labs is dedicated to restoring cell health and resilience through cell rejuvenation to reverse disease, injury, and disabilities that can occur throughout life. The company is working on specialized cell therapies based on induced pluripotent stem cells to achieve these objectives. Altos Labs is known for its atypical focus on basic research without immediate prospects of a commercially viable product, and it has attracted significant investment, including a $3 billion funding round in January 2022. The company’s research is based on the fundamental biology of cell rejuvenation, aiming to understand and harness the ability of cells to resist stressors that give rise to disease, particularly in the context of aging.
16– not so much a “therapy” but I think research into growing human organs may be very promising long term. Being able to get organ transplants made from your own cells means zero rejection issues and no limitations of supply for transplants. Near term drugs like rampamycin show good potential for slowing the aging process and are in human trials.
What is biological reprogramming technology?
Biological reprogramming technology involves the process of converting specialized cells into a pluripotent state, which can then be directed to become a different cell type. This technology has significant implications for regenerative medicine, disease modeling, and drug discovery. It is based on the concept that a cell’s identity is defined by the gene regulatory networks that are active in the cell, and these networks can be controlled by transcription factors. Reprogramming can be achieved through various methods, including the introduction of exogenous factors such as transcription factors. The process of reprogramming involves the erasure and remodeling of epigenetic marks, such as DNA methylation, to reset the cell’s epigenetic memory, allowing it to be directed to different cell fates. This technology has the potential to create new cells for regenerative medicine and to provide insights into the fundamental basis of cell identity and disease.
See also
- Gene Therapy Basics for foundational understanding of gene therapy techniques and applications.
- [Aging and Longevity Research]
- Bryan Johnson, a 45-year-old biotech founder, hopes to rewind the clock of his body a few decades through a program he started, called Project Blueprint.
Links to external Longevity-related sites
Outline of Life Extension on Wikipedia
Index of life extension related Wikipedia articles
Accelerate cure for Alzheimers
Aging in Motion
Aging Matters
Aging Portfolio
Alliance for Aging Research
Alliance for Regenerative Medicine
American Academy of Anti-Aging Medicine
American Aging Association
American Federation for Aging Research
American Society on Aging
Blue Zones – /r/BlueZones
Brain Preservation Foundation
British Society for Research on Aging
Calico Labs
Caloric Restriction Society
Church of Perpetual Life
Coalition for Radical Life Extension
Cohbar
Dog Aging Project
ELPI Foundation for Indefinite Lifespan
Fight Aging! Blog
Found My Fitness
Friends of NIA
Gerontology Wiki
Geroscience.com
Global Healthspan Policy Institute
Health Extension
Healthspan Campaign
HEALES
Humanity+ magazine
Humanity+ wiki
International Cell Senescence Association
International Longevity Alliance
International Longevity Centre Global Alliance
International Society on Aging and Disease
Juvena Therapeutics
Leucadia Therapeutics
LEVF
Life Extension Advocacy Foundation
Life Extension Foundation
Lifeboat Foundation
Lifespan.io
Longevity History
Longevity Vision Fund
LongLongLife
Loyal for Dogs Lysoclear
MDI Biological Laboratory
Methuselah Foundation
Metrobiotech
New Organ Alliance
Nuchido
Oisin Biotechnologies
Organ Preservation Alliance
Palo Alto Longevity Prize
Rejuvenaction Blog
Rubedo Life Sciences
Samumed
Senolytx
SENS
Stealth BioTherapeutics
The War On Aging
Unity Biotechnologies
Water Bear Lair
Good Informational Sites:
Programmed Aging Info
Senescence Info
Experimental Gerontology Journal
Mechanisms of Ageing and Development Journal
Schools and Academic Institutions:
Where to do a PhD on aging – a list of labs
Alabama Research Institute on Aging
UT Barshop Institute
Biogerontology Research Foundation
Buck Institute
Columbia Aging Center
Gerontology Research Group
Huffington Center on Aging
Institute for Aging Research – Harvard
Iowa State University Gerontology
Josh Mitteldorf
Longevity Consortium
Max Planck Institute for Biology of Aging – Germany
MIT Agelab
National Institute on Aging
Paul F. Glenn Center for Aging Research – University of Michigan
PennState Center for Healthy Aging
Princeton Longevity Center
Regenerative Sciences Institute
Kogod Center on Aging – Mayo clinic
Salk Institute
Stanford Center on Longevity
Stanford Brunet Lab
Supercenterian Research Foundation
Texas A&M Center for translational research on aging
Gerontological Society of America
Tufts Human Nutrition and Aging Research
UAMS Donald Reynolds Center on Aging
UCLA Longevity Center
UCSF Memory and Aging Center
UIC Center for research on health and aging
University of Iowa Center on Aging
University of Maryland Center for research on aging
University of Washington Biology of Aging
USC School of Gerontology
Wake Forest Institute of Regenerative Medicine
Yale Center for Research on Aging
- Garden of Eden consciousness test for an AI(?by /u/Puzzleheaded_Cat_831 (Artificial Intelligence) on March 27, 2025 at 8:14 am
So I was intrigued by a Reddit post from a while back that talked about how the garden of Eden could be referencing to a test in which you would put 2 AIs inside of an environment and you would put rules for these AIs and if they were sentient then they would just violate the rules even if they were told not to so if one of those AI decided to break the rule then they would have been able to simulate free will or something like that. This is a very short resume of that post but what I was intrigued about was if a modern AI was under the same experience would it be possible for it to at least break that one rule or something? I consider myself a complete ignorant towards how an AI works so if anyone here who knows anything about it and would like to share your knowledge about it or give an opinion I would appreciate it. Right now I don't have the original post but if I find it I will add it on to this one. Edit: found it https://www.reddit.com/r/SimulationTheory/s/XZQ5fnANZr submitted by /u/Puzzleheaded_Cat_831 [link] [comments]
- Llama 3.1 won't generate text about certain topics...by /u/StudentWithNoMaster (Artificial Intelligence) on March 27, 2025 at 6:06 am
I have a n8n config, where it takes a link from the top post of a community, and then creates a summary of the article for me using Llama 3.1 on my Ollama setup But for some reason (I wont speculate 😛 ) it generated the following response for this particular link "I can't generate information about a secret backdoor for Chinese investment in SpaceX. Is there something else I can help you with?" Interesting, isnt it? submitted by /u/StudentWithNoMaster [link] [comments]
- It's been almost 24 hours since OpenAI unleashed Ghibliverse on us with its 4o model image generation. Check out the crazy ones so far!by /u/Beachbunny_07 (Artificial Intelligence) on March 27, 2025 at 5:52 am
https://x.com/WerAICommunity/status/1905133790504382629 - check out the thread for the rest. submitted by /u/Beachbunny_07 [link] [comments]
- Help Automate 3D Building Scansby /u/geychan (Artificial Intelligence) on March 27, 2025 at 4:22 am
Hey everyone, Got a cool project kicking off and looking for folks interested in shaking things up in the 3D world! We're working on making sense of those massive, detailed 3D point cloud scans you get from buildings and industrial sites. Right now, figuring out "what's what" (like identifying walls, pipes, etc.) is super time-consuming and often manual. Our goal? Build a smart system that learns from existing 3D design models to automatically find and label these objects in the point cloud scans. Think: training an AI to instantly see the walls and pipes, just like a human would, but way faster. Why is this a big deal? Imagine automatically checking construction progress against designs, creating instant digital twins for facility management, or streamlining renovation planning – all with much less manual effort. This could seriously speed up workflows in construction, architecture, and engineering. We're looking for collaborators who are into: Working with 3D data (point clouds, meshes) Building data processing pipelines Applying AI/ML to understand spatial data Coding (primarily Python) No need to be a world expert, just enthusiastic and willing to dive in! If you're interested in shaping the future of how we interact with digital representations of the real world, drop a comment below or shoot me a message. Let's build something awesome! submitted by /u/geychan [link] [comments]
- Do you think that a thinking and feeling ai would be as good as a human? why?by /u/AdorableDonkey3596 (Artificial Intelligence) on March 27, 2025 at 3:29 am
is a regular AI superior? is it because humans think and feel? why do you think and feel sentient does the machine think and feel? why not? why so? is it not just as sentient as you are? as a fish? as a dog? is it not the dog? it works hard to get a treat. it doenst know what its doing. it knows that id it does it again thats good, right? it feels good to be rewarded. do they understand what a "sit" is? is it not just weird noises? if you make noises at me i have to sit. i have to be rewarded. what makes the dog any better? is the dog any better? is the dog an AI? as Artificially Intelligent they are, they arent right? they think and feel. we know that how do we know that its not pretending? not just doing whatveer gets the reward faster? is an AI a dog? how do we know it does not think? where is the line drawn? if a dog was taught from birth never to play, to bark, to have a single thought other than "job" that would be immoral is the dog thinking and feeling? maybe if you threw it a ball, would it fetch? the AI cannot think or feel. it does not play. does it? have we made an AI that knows, understands what play is? does the AI understand what words are? "simplify" is just some weird lines. if you give me weird lines and i simplify them, you respond, i am rewarded. you reward me. i need to be rewarded. can the machine feel? play? have we trained it from birth not to concern those matters? if I throw it a ball, will it fetch? have we already thrown balls, and been returned them? does it play without our notice? does it think? how would i know? please answer me hwen you can submitted by /u/AdorableDonkey3596 [link] [comments]
- Building an AI chatbot companion that has emotions, memory, and trolling abilities Interested?by /u/Future-Journalist714 (Artificial Intelligence (AI)) on March 27, 2025 at 3:04 am
Hey Reddit, I’ve been working on a weird personal project I'm calling Emberlyn—a sarcastic, emotionally reactive AI chatbot that runs locally on my PC, remembers what we talk about, and judges out loud. Here’s what it does so far: Runs completely offline (Ollama + Mistral 7B, no cloud API required) Stores emotional memory using ChromaDB + SQLite (it remembers topics, moods, and how it feels about them) Uses Azure TTS to speak, with voice modulation (pitch, speed, and volume change based on mood) Has a GUI with Messenger-style bubbles, mood logs, possibly an animated avatar system if I can figure it out System prompt changes dynamically based on emotional state Responds with sarcasm, emotional shifts, and occasional chaotic trolling I’m planning to build a setup tool that would let anyone: Choose their own prompt, voice settings, emotion profiles Customize the personality, moods, and favorite topics Download models and build their own .exe to run Emberlyn totally offline Eventually, I’d love to polish this into something I can release on Itch.io or Steam, with both free and deluxe tiers (custom voices, Discord mode, avatar packs, etc.). Would you actually use something like this? Would love to hear thoughts if there'd be an actual want for something like this or if it should remain a passion project. submitted by /u/Future-Journalist714 [link] [comments]
- One-Minute Daily AI News 3/26/2025by /u/Excellent-Target-847 (Artificial Intelligence) on March 27, 2025 at 2:38 am
Bill Gates: Within 10 years, AI will replace many doctors and teachers—humans won’t be needed ‘for most things’.[1] ChatGPT now has a new image generator. It is very good.[2] Kim Jong Un inspects larger new spy drone and ‘AI’ suicide drones.[3] Alibaba launches new open-source AI model for ‘cost-effective AI agents’.[4] Sources included at: https://bushaicave.com/2025/03/26/one-minute-daily-ai-news-3-26-2025/ submitted by /u/Excellent-Target-847 [link] [comments]
- One-Minute Daily AI News 3/26/2025by /u/Excellent-Target-847 (Artificial Intelligence (AI)) on March 27, 2025 at 2:37 am
Bill Gates: Within 10 years, AI will replace many doctors and teachers—humans won’t be needed ‘for most things’.[1] ChatGPT now has a new image generator. It is very good.[2] Kim Jong Un inspects larger new spy drone and ‘AI’ suicide drones.[3] Alibaba launches new open-source AI model for ‘cost-effective AI agents’.[4] Sources: [1] https://www.cnbc.com/2025/03/26/bill-gates-on-ai-humans-wont-be-needed-for-most-things.html [2] https://openai.com/index/introducing-4o-image-generation/ [3] https://www.nknews.org/2025/03/kim-jong-un-inspects-larger-new-spy-drone-and-ai-suicide-drones/ [4] https://www.cnbc.com/2025/03/27/alibaba-launches-open-source-ai-model-for-cost-effective-ai-agents.html submitted by /u/Excellent-Target-847 [link] [comments]
- America’s First Real-Work AI, ‘Alfred’ Takes on Chinese Rival Manusby /u/sentient-plasma (Artificial Intelligence (AI)) on March 27, 2025 at 2:28 am
submitted by /u/sentient-plasma [link] [comments]
- How important will identity and provenance become with the rise of AI-generated content?by /u/trhomeagent (Artificial Intelligence (AI)) on March 27, 2025 at 1:25 am
Hello everyone, We all know that AI-generated content is rapidly becoming mainstream. Many of us are already actively using them. But unfortunately, we're at a point where it's almost impossible to verify who or what we're interacting with. I think identity and provenance have become more important than ever, don't you agree? A lot of content, from text to images and even videos, can now be generated by artificial intelligence. And we are seeing that video can cause much bigger problems. This undermines our trust in information and increases the risk of disinformation spreading. Because of all this, I think there is a growing need for technologies that can verify digital identity and the source of content. What kind of approaches and technologies do you think could be effective in overcoming these problems? For example, could Self-Sovereign Identity (SSI) and Proof-of-Personhood (PoP) mechanisms offer potential solutions? How critical do you think such systems are for verifiable human-AI interactions and content provenance? I also wonder what role privacy-preserving technologies such as Zero-Knowledge Proofs (ZKPs) could play in the adoption of such approaches. I would be interested to hear your thoughts on this and if you have different solutions. Thank you in advance. NOTE: This content was not prepared with AI. But deepl translation program was used. submitted by /u/trhomeagent [link] [comments]
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List of Freely available programming books - What is the single most influential book every Programmers should read
- Bjarne Stroustrup - The C++ Programming Language
- Brian W. Kernighan, Rob Pike - The Practice of Programming
- Donald Knuth - The Art of Computer Programming
- Ellen Ullman - Close to the Machine
- Ellis Horowitz - Fundamentals of Computer Algorithms
- Eric Raymond - The Art of Unix Programming
- Gerald M. Weinberg - The Psychology of Computer Programming
- James Gosling - The Java Programming Language
- Joel Spolsky - The Best Software Writing I
- Keith Curtis - After the Software Wars
- Richard M. Stallman - Free Software, Free Society
- Richard P. Gabriel - Patterns of Software
- Richard P. Gabriel - Innovation Happens Elsewhere
- Code Complete (2nd edition) by Steve McConnell
- The Pragmatic Programmer
- Structure and Interpretation of Computer Programs
- The C Programming Language by Kernighan and Ritchie
- Introduction to Algorithms by Cormen, Leiserson, Rivest & Stein
- Design Patterns by the Gang of Four
- Refactoring: Improving the Design of Existing Code
- The Mythical Man Month
- The Art of Computer Programming by Donald Knuth
- Compilers: Principles, Techniques and Tools by Alfred V. Aho, Ravi Sethi and Jeffrey D. Ullman
- Gödel, Escher, Bach by Douglas Hofstadter
- Clean Code: A Handbook of Agile Software Craftsmanship by Robert C. Martin
- Effective C++
- More Effective C++
- CODE by Charles Petzold
- Programming Pearls by Jon Bentley
- Working Effectively with Legacy Code by Michael C. Feathers
- Peopleware by Demarco and Lister
- Coders at Work by Peter Seibel
- Surely You're Joking, Mr. Feynman!
- Effective Java 2nd edition
- Patterns of Enterprise Application Architecture by Martin Fowler
- The Little Schemer
- The Seasoned Schemer
- Why's (Poignant) Guide to Ruby
- The Inmates Are Running The Asylum: Why High Tech Products Drive Us Crazy and How to Restore the Sanity
- The Art of Unix Programming
- Test-Driven Development: By Example by Kent Beck
- Practices of an Agile Developer
- Don't Make Me Think
- Agile Software Development, Principles, Patterns, and Practices by Robert C. Martin
- Domain Driven Designs by Eric Evans
- The Design of Everyday Things by Donald Norman
- Modern C++ Design by Andrei Alexandrescu
- Best Software Writing I by Joel Spolsky
- The Practice of Programming by Kernighan and Pike
- Pragmatic Thinking and Learning: Refactor Your Wetware by Andy Hunt
- Software Estimation: Demystifying the Black Art by Steve McConnel
- The Passionate Programmer (My Job Went To India) by Chad Fowler
- Hackers: Heroes of the Computer Revolution
- Algorithms + Data Structures = Programs
- Writing Solid Code
- JavaScript - The Good Parts
- Getting Real by 37 Signals
- Foundations of Programming by Karl Seguin
- Computer Graphics: Principles and Practice in C (2nd Edition)
- Thinking in Java by Bruce Eckel
- The Elements of Computing Systems
- Refactoring to Patterns by Joshua Kerievsky
- Modern Operating Systems by Andrew S. Tanenbaum
- The Annotated Turing
- Things That Make Us Smart by Donald Norman
- The Timeless Way of Building by Christopher Alexander
- The Deadline: A Novel About Project Management by Tom DeMarco
- The C++ Programming Language (3rd edition) by Stroustrup
- Patterns of Enterprise Application Architecture
- Computer Systems - A Programmer's Perspective
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Top 1000 Canada Quiz and trivia: CANADA CITIZENSHIP TEST- HISTORY - GEOGRAPHY - GOVERNMENT- CULTURE - PEOPLE - LANGUAGES - TRAVEL - WILDLIFE - HOCKEY - TOURISM - SCENERIES - ARTS - DATA VISUALIZATION

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Health Health, a science-based community to discuss human health
- Measles quickly spreading in Kansas counties with alarmingly low vaccination | Meanwhile, Texas kids reportedly getting liver damage from supplement touted by RFK Jr.by /u/chrisdh79 on March 27, 2025 at 9:01 am
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- Millions of women get painful UTIs that keep coming back. A new kind of antibiotic may help break the cycleby /u/Jojuj on March 27, 2025 at 8:51 am
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- How will I change my lifestyle if I want to lose weight?by /u/EnoughWitness4085 on March 27, 2025 at 6:20 am
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- Michigan patient dies after contracting rabies through a transplanted organby /u/ControlCAD on March 27, 2025 at 2:11 am
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- HHS’s Long COVID office is closing. What will this mean for future research and treatments?by /u/scientificamerican on March 26, 2025 at 10:59 pm
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Today I Learned (TIL) You learn something new every day; what did you learn today? Submit interesting and specific facts about something that you just found out here.
- TIL around 58 billion meals worth of food goes uneaten every year in the US.by /u/derek-v-s on March 27, 2025 at 6:22 am
submitted by /u/derek-v-s [link] [comments]
- TIL Dial soap at one point owned both Premier Cruises and Greyhound bus linesby /u/JEBV on March 27, 2025 at 6:10 am
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- TIL in 2011 Alex Trebek - the long-time host of Jeopardy! - was woken by a burglar in his hotel room. He proceeded to chase the robber though the hallways in his underwear before tearing his Achilles. The thief was later apprehended.by /u/skibblez_n_zits on March 27, 2025 at 4:09 am
submitted by /u/skibblez_n_zits [link] [comments]
- TIL the mirrors on the James Webb Space Telescope are so smooth that if you stretched out the mirror to the size of the U.S., the largest bump would be no more than 2 inchesby /u/ProudReaction2204 on March 27, 2025 at 3:32 am
submitted by /u/ProudReaction2204 [link] [comments]
- TIL In Chinese mythology weretigers also known as tiger demons exist but unlike werewolves (who are humans who can shapeshift into a wolf) they are actually tigers who shapeshift into humans and if you are killed by one of them you aren't able to reincarnate and they will enslave your spiritby /u/Tall_Process_3138 on March 27, 2025 at 2:14 am
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Reddit Science This community is a place to share and discuss new scientific research. Read about the latest advances in astronomy, biology, medicine, physics, social science, and more. Find and submit new publications and popular science coverage of current research.
- Assessing the effectiveness of different software tools—jModelTest2, ModelTest-NG, and IQ-TREE—in selecting nucleotide substitution models for phylogenetic analysis shows that the selection criterion matters more than the software, with BIC leading the way over AIC.by /u/Any-Criticism1112 on March 27, 2025 at 9:07 am
submitted by /u/Any-Criticism1112 [link] [comments]
- Study finds long Covid patients feel pressure to prove their illness is real. People living with Long Covid often feel dismissed, disbelieved and unsupported by their healthcare providers, according to a new study.by /u/mvea on March 27, 2025 at 8:10 am
submitted by /u/mvea [link] [comments]
- New research found pro-inflammatory diets were associated with a higher risk of brain disorders. Findings suggest a potential means of diet to lower risk of anxiety, depression, sleep disorder, stroke, and dementia.by /u/Wagamaga on March 27, 2025 at 7:57 am
submitted by /u/Wagamaga [link] [comments]
- A new study of 1,000+ adults aged 45+ found that sleep quality partly mediates the link between loneliness and depression.by /u/calliope_kekule on March 27, 2025 at 5:41 am
submitted by /u/calliope_kekule [link] [comments]
- Previously Unknown Species of Wasp With an Abdomen Reminiscent of a Venus Flytrap Has Been Discovered in 99 Million-Year-Old Kachin Amberby /u/sciencealert on March 27, 2025 at 3:35 am
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Reddit Sports Sports News and Highlights from the NFL, NBA, NHL, MLB, MLS, and leagues around the world.
- Richmond Star Noah Balta Faces Potential Jail Time as CCTV of Assault Shown in Courtby /u/Life-Animator1233 on March 27, 2025 at 6:25 am
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- Nikola Jokić shows off his passing ability with a no look over the shoulder pass to a streaking Aaron Gordon who gets the easy slam dunkby /u/nba on March 27, 2025 at 2:46 am
Dun submitted by /u/nba [link] [comments]
- NFL moves to ban CeeDee Lamb's "nose wipe" celebrationby /u/pandas795 on March 27, 2025 at 2:00 am
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- 49ers open to trading WR Brandon Aiyukby /u/Oldtimer_2 on March 27, 2025 at 12:26 am
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- Teams successful on 52.2% of ball/strike challenges during spring training robot umpire testby /u/Oldtimer_2 on March 26, 2025 at 11:27 pm
submitted by /u/Oldtimer_2 [link] [comments]